Neuromedin U receptor 2

NMUR2
Identifiers
Aliases	NMUR2 , FM-4, FM4, NMU-R2, NMU2R, TGR-1, TGR1, Neuromedin U receptor 2
External IDs	OMIM: 605108; MGI: 2441765; HomoloGene: 49618; GeneCards: NMUR2; OMA:NMUR2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q33.1 Start 152,391,546 bp [1] End 152,433,368 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.3 Start 55,915,813 bp [2] End 55,931,836 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle testicle mucosa of ileum deltoid muscle corpus callosum skin of thigh C1 segment internal globus pallidus right testis right lung Top expressed in embryo submandibular gland cervix jejunum duodenum skin of abdomen trachea stomach More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding signal transducer activity neuromedin U binding neuropeptide receptor activity neuromedin U receptor activity intracellular calcium activated chloride channel activity GTP binding G protein-coupled receptor activity Cellular component integral component of membrane membrane plasma membrane intracellular anatomical structure Biological process reduction of food intake in response to dietary excess calcium ion transport phospholipase C-activating G protein-coupled receptor signaling pathway activation of phospholipase A2 activity feeding behavior inositol phosphate-mediated signaling regulation of smooth muscle contraction arachidonic acid secretion positive regulation of cytosolic calcium ion concentration cell-cell signaling response to pain calcium-mediated signaling signal transduction grooming behavior central nervous system development G protein-coupled receptor signaling pathway neuropeptide signaling pathway ion transmembrane transport regulation of sensory perception of pain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56923 216749 Ensembl ENSG00000132911 ENSMUSG00000037393 UniProt Q9GZQ4 Q8BZ39 RefSeq (mRNA) NM_020167 NM_153079 RefSeq (protein) NP_064552 NP_694719 Location (UCSC) Chr 5: 152.39 – 152.43 Mb Chr 11: 55.92 – 55.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuromedin-U receptor 2 is a protein that in humans is encoded by the NMUR2 gene. ^{[5] [6] [7]}

Ligands

Agonists

• synephrine ^[8]

See also

• Neuromedin U receptor

References

1. GRCh38: Ensembl release 89: ENSG00000132911 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037393 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tate CG, Grisshammer R (Jan 1997). "Heterologous expression of G-protein-coupled receptors". Trends Biotechnol. 14 (11): 426–30. doi:10.1016/0167-7799(96)10059-7. PMID   8940772.
6. Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q (Jul 2000). "Identification of receptors for neuromedin U and its role in feeding". Nature. 406 (6791): 70–4. doi:10.1038/35017610. PMID   10894543. S2CID   205007370.
7. "Entrez Gene: NMUR2 neuromedin U receptor 2".
8. Zheng X, Guo L, Wang D, Deng X (2014). "p-Synephrine: a novel agonist for neuromedin U2 receptor". Biol Pharm Bull. 37 (5): 764–70. doi: 10.1248/bpb.b13-00788 . PMID   24598981.

Further reading

• Hosoya M, Moriya T, Kawamata Y, et al. (2000). "Identification and functional characterization of a novel subtype of neuromedin U receptor". J. Biol. Chem. 275 (38): 29528–32. doi: 10.1074/jbc.M004261200 . PMID   10887190.
• Raddatz R, Wilson AE, Artymyshyn R, et al. (2000). "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system". J. Biol. Chem. 275 (42): 32452–9. doi: 10.1074/jbc.M004613200 . PMID   10899166.
• Shan L, Qiao X, Crona JH, et al. (2001). "Identification of a novel neuromedin U receptor subtype expressed in the central nervous system". J. Biol. Chem. 275 (50): 39482–6. doi: 10.1074/jbc.C000522200 . PMID   11010960.
• Fernández Alvarez C, Debeljuk L, Díaz Rodríguez E, Díaz López B (2003). "Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin". Peptides. 23 (9): 1617–23. doi:10.1016/S0196-9781(02)00099-2. hdl: 10651/41212 . PMID   12217422. S2CID   9986371.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Bhattacharyya S, Luan J, Farooqi IS, et al. (2004). "Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor". J. Endocrinol. 183 (1): 115–20. doi: 10.1677/joe.1.05830 . PMID   15525579.
• Mori K, Miyazato M, Ida T, et al. (2005). "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system". EMBO J. 24 (2): 325–35. doi:10.1038/sj.emboj.7600526. PMC   545815 . PMID   15635449.
• Fang L, Zhang M, Li C, et al. (2006). "Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones". Neurosci. Lett. 404 (1–2): 148–53. doi:10.1016/j.neulet.2006.05.034. PMID   16781063. S2CID   26500367.

External links

• "Neuromedin U Receptors: NMU2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.