Metabotropic glutamate receptor 8

Last updated
GRM8
Identifiers
Aliases GRM8 , GLUR8, GPRC1H, MGLUR8, mGlu8, glutamate metabotropic receptor 8
External IDs OMIM: 601116 MGI: 1351345 HomoloGene: 654 GeneCards: GRM8
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008174
NM_001311072
NM_001361125

RefSeq (protein)

NP_001298001
NP_032200
NP_001348054

Location (UCSC) Chr 7: 126.44 – 127.25 Mb Chr 6: 27.28 – 28.14 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Metabotropic glutamate receptor 8 is a protein that in humans is encoded by the GRM8 gene. [5] [6]

Contents

Function

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined. [6]

Ligands

See also

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000179603 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024211 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (January 1996). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q". Genomics. 31 (2): 230–233. doi: 10.1006/geno.1996.0036 . PMID   8824806.
  6. 1 2 "Entrez Gene: GRM8 glutamate receptor, metabotropic 8".
  7. Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE (March 2001). "(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord". Neuropharmacology. 40 (3): 311–318. doi:10.1016/S0028-3908(00)00169-6. PMID   11166323. S2CID   2872874.
  8. Duvoisin RM, Pfankuch T, Wilson JM, Grabell J, Chhajlani V, Brown DG, et al. (October 2010). "Acute pharmacological modulation of mGluR8 reduces measures of anxiety". Behavioural Brain Research. 212 (2): 168–173. doi:10.1016/j.bbr.2010.04.006. PMC   2892883 . PMID   20385173.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.