TAAR9

TAAR9
Identifiers
Aliases	TAAR9 , TA3, TAR3, TAR9, TRAR3, trace amine associated receptor 9 (gene/pseudogene), trace amine associated receptor 9
External IDs	OMIM: 608282; MGI: 3527454; HomoloGene: 65286; GeneCards: TAAR9; OMA:TAAR9 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q23.2 Start 132,538,290 bp [1] End 132,539,336 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A4 Start 23,984,386 bp [2] End 23,985,432 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in material anatomical entity Top expressed in embryo primary oocyte secondary oocyte zygote More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity G protein-coupled receptor activity trace-amine receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 134860 503558 Ensembl ENSG00000237110 ENSMUSG00000037424 UniProt Q96RI9 Q5QD04 RefSeq (mRNA) NM_175057 NM_001010831 RefSeq (protein) NP_778227 NP_001010831 Location (UCSC) Chr 6: 132.54 – 132.54 Mb Chr 10: 23.98 – 23.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene. ^{[5] [6]}

TAAR9 is a member of a large family of rhodopsin G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM] ^[6] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants. ^{[7] [8]}

Recent research has demonstrated that deletion of the TAAR9 gene in rats leads to significant changes in both the CNS and the periphery. In the central nervous system, knockout of this gene slightly increases hippocampal serotonin and alters grooming behavior. ^[9] Peripherally, blood analysis revealed decreased levels of low-density lipoprotein cholesterol in the blood. ^[10] Additionally, TAAR9 appears to play a significant role in maintaining microbiota homeostasis. In TAAR9-KO rats, the microbiome structure exhibited greater variability than in wild-type littermates. ^[11]

See also

• Trace amine-associated receptor

References

1. GRCh38: Ensembl release 89: ENSG00000237110 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037424 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID   15718104.
6. "Entrez Gene: TAAR9 trace amine associated receptor 9".
7. Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, Liberles SD (July 2012). "Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity". ACS Chemical Biology. 7 (7): 1184–9. doi:10.1021/cb300111e. PMC   3401279 . PMID   22545963.
8. Liberles SD (October 2015). "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Current Opinion in Neurobiology. 34: 1–7. doi:10.1016/j.conb.2015.01.001. PMC   4508243 . PMID   25616211.
9. Zhukov IS, Karpova IV, Murtazina RZ, Alnefeesi Y, Korenkova OM, Tissen IY, Palchikova SA, Tokareva LA, Pyurveev SS, Shabanov PD, Kubarskaya LG, Rozhko MA, Zernova EB, Zolotoverkhaja EA, Volnova AB, Kalueff AV, Alenina NV, Gainetdinov RR (12 November 2025). "TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats". Frontiers in Pharmacology. 16. doi:https://doi.org/10.3389/fphar.2025.1684029.{{cite journal}}: Check |doi= value (help); External link in |doi= (help)
10. Murtazina RZ, Zhukov IS, Korenkova OM, Popova EA, Kuvarzin SR, Efimova EV, et al. (March 2021). "Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels". International Journal of Molecular Sciences. 22 (6): 2942. doi: 10.3390/ijms22062942 . PMC   7998418 . PMID   33799339.
11. Zhukov IS, Vaganova AN, Murtazina RZ, Alferova LS, Ermolenko EI, Gainetdinov RR (6 December 2022). "Gut Microbiota Alterations in Trace Amine-Associated Receptor 9 (TAAR9) Knockout Rats". Biomolecules. 12 (12): 1823. doi:https://doi.org/10.3390/biom12121823.{{cite journal}}: Check |doi= value (help); External link in |doi= (help)

Further reading

• Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, et al. (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 8966–71. Bibcode:2001PNAS...98.8966B. doi: 10.1073/pnas.151105198 . PMC   55357 . PMID   11459929.
• Vanti WB, Muglia P, Nguyen T, Cheng R, Kennedy JL, George SR, O'Dowd BF (November 2003). "Discovery of a null mutation in a human trace amine receptor gene". Genomics. 82 (5): 531–6. doi:10.1016/S0888-7543(03)00173-3. PMID   14559210.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.