GPR135

GPR135
Identifiers
Aliases	GPR135 , HUMNPIIY20, G protein-coupled receptor 135
External IDs	OMIM: 607970; MGI: 2676315; HomoloGene: 11211; GeneCards: GPR135; OMA:GPR135 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q23.1 Start 59,429,022 bp [1] End 59,465,380 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C3 Start 72,114,750 bp [2] End 72,117,899 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm testicle right uterine tube buccal mucosa cell right coronary artery ventricular zone left coronary artery popliteal artery Top expressed in substantia nigra Region I of hippocampus proper ventromedial nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus arcuate nucleus lateral hypothalamus fossa lateral septal nucleus anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity protein binding arrestin family protein binding Cellular component integral component of membrane membrane plasma membrane endosome endosome membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64582 238252 Ensembl ENSG00000181619 ENSMUSG00000043398 UniProt Q8IZ08 Q7TQP2 RefSeq (mRNA) NM_022571 NM_181752 RefSeq (protein) NP_072093 NP_861417 Location (UCSC) Chr 14: 59.43 – 59.47 Mb Chr 12: 72.11 – 72.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 135 is a protein that in humans is encoded by the GPR135 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000181619 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043398 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett. 554 (3): 381–8. doi: 10.1016/S0014-5793(03)01196-7 . PMID   14623098. S2CID   11563502.
6. "Entrez Gene: GPR135 G protein-coupled receptor 135".

Further reading

• Kunz D, Gerard NP, Gerard C (1992). "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog". J. Biol. Chem. 267 (13): 9101–6. doi: 10.1016/S0021-9258(19)50394-5 . PMID   1374385.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi: 10.1073/pnas.0230374100 . PMC   153653 . PMID   12679517.
• Vanti WB, Nguyen T, Cheng R, et al. (2003). "Novel human G-protein-coupled receptors". Biochem. Biophys. Res. Commun. 305 (1): 67–71. doi:10.1016/S0006-291X(03)00709-5. PMID   12732197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.