TAS2R8

Last updated
TAS2R8
Identifiers
Aliases TAS2R8 , T2R8, TRB5, taste 2 receptor member 8
External IDs OMIM: 604794 HomoloGene: 88894 GeneCards: TAS2R8
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_023918

n/a

RefSeq (protein)

NP_076407

n/a

Location (UCSC) Chr 12: 10.81 – 10.81 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Taste receptor type 2 member 8 is a protein that in humans is encoded by the TAS2R8 gene. [3] [4] [5]

Contents

Function

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [5]

See also

Related Research Articles

TAS2R16

TAS2R16 is a human gene that encodes for a receptor that may play a role in the perception of bitterness.

TAS2R1

Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene. It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop. Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.

TAS2R3

Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.

TAS2R4

Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene.

TAS2R9

Taste receptor type 2 member 9 is a protein that in humans is encoded by the TAS2R9 gene.

TAS2R10

Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene.

TAS2R13

Taste receptor type 2 member 13 is a protein that in humans is encoded by the TAS2R13 gene.

TAS2R14

Taste receptor type 2 member 14 is a protein that in humans is encoded by the TAS2R14 gene.

TAS2R5

Taste receptor type 2 member 5 is a protein that in humans is encoded by the TAS2R5 gene.

TAS2R7

Taste receptor type 2 member 7 is a protein that in humans is encoded by the TAS2R7 gene.

TAS2R39

Taste receptor type 2 member 39 is a protein that in humans is encoded by the TAS2R39 gene.

TAS2R40

Taste receptor type 2 member 40 is a protein that in humans is encoded by the TAS2R40 gene.

TAS2R41

Taste receptor type 2 member 41 is a protein that in humans is encoded by the TAS2R41 gene.

TAS2R45

Taste receptor type 2 member 45 is a protein that in humans is encoded by the TAS2R45 gene.

TAS2R46

Taste receptor type 2 member 46 is a protein that in humans is encoded by the TAS2R46 gene.

TAS2R30 Protein-coding gene in humans

Taste receptor type 2 member 30 is a protein that in humans is encoded by the TAS2R30 gene.

TAS2R19

Taste receptor type 2 member 19 is a protein that in humans is encoded by the TAS2R19 gene. It seems to be involved in the perception of salt and bitter tastes.

TAS2R20

Taste receptor type 2 member 20 is a protein that in humans is encoded by the TAS2R20 gene.

TAS2R50

Taste receptor type 2 member 50 is a protein that in humans is encoded by the TAS2R50 gene.

TAS2R60

Taste receptor type 2 member 60 is a protein that in humans is encoded by the TAS2R60 gene.

References

  1. 1 2 3 ENSG00000121314, ENSG00000272712 GRCh38: Ensembl release 89: ENSG00000277316, ENSG00000121314, ENSG00000272712 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi: 10.1016/S0092-8674(00)80705-9 . PMID   10761934. S2CID   14604586.
  4. Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. Bibcode:2000Natur.404..601M. doi:10.1038/35007072. PMID   10766242. S2CID   4336913.
  5. 1 2 "Entrez Gene: TAS2R8 taste receptor, type 2, member 8".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.