GPR12

GPR12
Identifiers
Aliases	GPR12 , GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDs	OMIM: 600752 MGI: 101909 HomoloGene: 3868 GeneCards: GPR12
Gene location (Human)
Chr.	Chromosome 13 (human)
End	26,760,786 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	146,522,049 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; cerebellar hemisphere; ; nucleus accumbens; ; caudate nucleus; ; prefrontal cortex; ; putamen; ; Brodmann area 9; ; cingulate gyrus; ; pancreatic ductal cell; ; tibialis anterior muscle;
	Top expressed in
	entorhinal cortex; ; superior frontal gyrus; ; hippocampus proper; ; Region I of hippocampus proper; ; caudate nucleus; ; secondary oocyte; ; medial dorsal nucleus; ; nucleus accumbens; ; barrel cortex; ; amygdala;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity ; signal transducer activity ; phosphatidylcholine binding ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; membrane ;
Biological process	G protein-coupled receptor signaling pathway ; cellular calcium ion homeostasis ; signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	2835
	14738
	ENSG00000132975
	ENSMUSG00000041468
	P47775
	P35412
	NM_005288
NM_001010941 ; NM_008151 ; NM_001359055 ; NM_001359056 ; NM_001359057 ;
	NM_001359058
	NP_005279
NP_001010941 ; NP_032177 ; NP_001345984 ; NP_001345985 ; NP_001345986 ;
	NP_001345987
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 27, 2023

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.^[5]^[6]^[7]

Ligands

Inverse agonists

Cannabidiol ^[9]

Evolution

Paralogues

Source:^[10]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132975 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041468 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (December 1993). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Letters. 336 (2): 317–22. doi: 10.1016/0014-5793(93)80828-I . PMID 8262253. S2CID 31345248.
↑ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
↑ "Entrez Gene: GPR12 G protein-coupled receptor 12".
↑ Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, et al. (September 2006). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–66. doi:10.1016/j.bbrc.2006.07.090. PMID 16887097.
↑ Brown KJ, Laun AS, Song ZH (November 2017). "Cannabidiol, a novel inverse agonist for GPR12". Biochemical and Biophysical Research Communications. 493 (1): 451–454. doi:10.1016/j.bbrc.2017.09.001. PMC 5849771 . PMID 28888984.
↑ "GeneCards®: The Human Gene Database".