MRGPRX2

MRGPRX2
Identifiers
Aliases	MRGPRX2 , MGRG3, MRGX2, MAS related GPR family member X2
External IDs	OMIM: 607228 MGI: 3588270 HomoloGene: 24986 GeneCards: MRGPRX2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.1 Start 19,054,455 bp [1] End 19,060,717 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B4 Start 48,128,367 bp [2] End 48,149,069 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen subcutaneous adipose tissue rectum urinary bladder fundus vagina gastric mucosa smooth muscle tissue breast mammary gland Top expressed in zone of skin quadriceps femoris muscle lip esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function neuropeptide binding signal transducer activity mast cell secretagogue receptor activity G protein-coupled receptor activity Cellular component plasma membrane membrane integral component of membrane mast cell granule integral component of plasma membrane Biological process sleep positive regulation of cytokinesis mast cell activation G protein-coupled receptor signaling pathway signal transduction sensory perception of pain mast cell degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117194 243978 Ensembl ENSG00000183695 ENSMUSG00000074109 UniProt Q96LB1 Q3UG50 RefSeq (mRNA) NM_001303615 NM_054030 NM_001034868 RefSeq (protein) NP_001290544 NP_473371 NP_001030040 Location (UCSC) Chr 11: 19.05 – 19.06 Mb Chr 7: 48.13 – 48.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene. ^{[5] [6]} It is most abundant on cutaneous mast cells.

Agonists are gyrase inhibitors like ciprofloxacin and non-depolarizing neuromuscular blocking agents like atracurium as well as vancomycin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions.

See also

• MAS1 oncogene

References

1. GRCh38: Ensembl release 89: ENSG00000183695 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074109 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi: 10.1016/S0092-8674(01)00483-4 . PMID   11551509.
6. "Entrez Gene: MRGPRX2 MAS-related GPR, member X2".

Further reading

• Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi: 10.1016/S0014-5793(02)02775-8 . PMID   12044878. S2CID   7116392.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Robas N, Mead E, Fidock M (2004). "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion". J. Biol. Chem. 278 (45): 44400–44404. doi: 10.1074/jbc.M302456200 . PMID   12915402.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yang S, Liu Y, Lin AA, et al. (2005). "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception". Gene. 352: 30–35. doi:10.1016/j.gene.2005.03.001. PMID   15862286.