MRGPRX2

Last updated
MRGPRX2
Identifiers
Aliases MRGPRX2 , MGRG3, MRGX2, MAS related GPR family member X2
External IDs OMIM: 607228; MGI: 3588270; HomoloGene: 24986; GeneCards: MRGPRX2; OMA:MRGPRX2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303615
NM_054030

NM_001034868

RefSeq (protein)

NP_001290544
NP_473371

NP_001030040

Location (UCSC) Chr 11: 19.05 – 19.06 Mb Chr 7: 48.13 – 48.15 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene. [5] [6] It is most abundant on cutaneous mast cells, sensory neurons, and keratinocytes. [7]

Contents

Activation of MRGPRX2 on mast cells leads to IgE-independent type 1 hypersensitivity-like symptoms, also known as pseudoallergic reactions, although more rapid and brief. Medications identified to cause MRGPRX2 activation including neuromuscular blocking agents (NMBA) (except for succinylcholine), antibiotics like DNA gyrase inhibitor fluoroquinolones or cell wall synthesis inhibitor vancomycin (which caused Red Man syndrome), icatibant, leuprolide, and morphine. [7]

See also

Related Research Articles

Histamine H<sub>2</sub> receptor Mammalian protein found in Homo sapiens

H2 receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals. They are positively coupled to adenylate cyclase via Gs alpha subunit. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. PKA functions to phosphorylate certain proteins, affecting their activity. The drug betazole is an example of a histamine H2 receptor agonist.

<span class="mw-page-title-main">TRPC4</span> Protein and coding gene in humans

The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.

<span class="mw-page-title-main">TRPM3</span> Protein-coding gene in the species Homo sapiens

Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.

<span class="mw-page-title-main">MAS1</span> Protein-coding gene in the species Homo sapiens

MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor, is a protein that in humans is encoded by the MAS1 gene. The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.

<span class="mw-page-title-main">G protein-coupled bile acid receptor</span> Protein-coding gene in the species Homo sapiens

The G protein-coupled bile acid receptor 1 (GPBAR1) also known as G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or Takeda G protein-coupled receptor 5 (TGR5) is a protein that in humans is encoded by the GPBAR1 gene.

<span class="mw-page-title-main">Brain-specific angiogenesis inhibitor 3</span> Protein-coding gene in the species Homo sapiens

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.

<span class="mw-page-title-main">TAAR2</span> Protein-coding gene in the species Homo sapiens

Trace amine-associated receptor 2 (TAAR2), formerly known as G protein-coupled receptor 58 (GPR58), is a protein that in humans is encoded by the TAAR2 gene. TAAR2 is coexpressed with Gα proteins; however, as of February 2017, its signal transduction mechanisms have not been determined.

<span class="mw-page-title-main">OPN3</span> Protein-coding gene in the species Homo sapiens

Opsin-3 also known as encephalopsin or panopsin is a protein that, in humans, is encoded by the OPN3 gene. Alternative splicing of this gene results in multiple transcript variants encoding different protein isoforms.

<span class="mw-page-title-main">Hydroxycarboxylic acid receptor 1</span> Protein-coding gene in the species Homo sapiens

Hydroxycarboxylic acid receptor 1 (HCA1), formerly known as G protein-coupled receptor 81 (GPR81), is a protein that in humans is encoded by the HCAR1 gene. HCA1, like the other hydroxycarboxylic acid receptors HCA2 and HCA3, is a Gi/o-coupled G protein-coupled receptor (GPCR). The primary endogenous agonist of HCA1 is lactic acid (and its conjugate base, lactate). More recently, 3,5-dihydroxybenzoic acid has been reported to activate HCA1.

<span class="mw-page-title-main">P2RY10</span> Protein-coding gene in the species Homo sapiens

Putative P2Y purinoceptor 10 is a protein that, in humans, is encoded by the P2RY10 gene.

<span class="mw-page-title-main">MRGPRD</span> Protein-coding gene in the species Homo sapiens

Mas-related G-protein coupled receptor member D is a protein that in humans is encoded by the MRGPRD gene.

<span class="mw-page-title-main">MRGPRE</span> Protein-coding gene in humans

Mas-related G-protein coupled receptor member E is a protein that in humans is encoded by the MRGPRE gene.

<span class="mw-page-title-main">MAS1L</span> Protein-coding gene in the species Homo sapiens

Mas-related G-protein coupled receptor MRG is a protein that in humans is encoded by the MAS1L gene.

<span class="mw-page-title-main">GPRC5D</span> Protein-coding gene in the species Homo sapiens

G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene.

<span class="mw-page-title-main">MRGPRX3</span> Protein-coding gene in the species Homo sapiens

Mas-related G-protein coupled receptor member X3 is a protein that in humans is encoded by the MRGPRX3 gene.

<span class="mw-page-title-main">MRGPRX4</span> Protein-coding gene in the species Homo sapiens

Mas-related G-protein coupled receptor member X4 is a protein that in humans is encoded by the MRGPRX4 gene.

<span class="mw-page-title-main">MRGPRX1</span> Protein-coding gene in the species Homo sapiens

Mas-related G-protein coupled receptor member X1 is a protein that in humans is encoded by the MRGPRX1 gene.

<span class="mw-page-title-main">GPRC6A</span> Protein-coding gene in the species Homo sapiens

G protein-coupled receptor family C group 6 member A (GPRC6A) is a protein that in humans is encoded by the GPRC6A gene. This protein functions as a receptor of L-α-amino acids, cations, osteocalcin, and steroids. It is a membrane androgen receptor.

<span class="mw-page-title-main">TNFRSF19</span> Protein-coding gene in the species Homo sapiens

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.

<span class="mw-page-title-main">GFRA2 (gene)</span> Protein-coding gene in the species Homo sapiens

GDNF family receptor alpha-2 (GFRα2), also known as the neurturin receptor, is a protein that in humans is encoded by the GFRA2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183695 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074109 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (September 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi: 10.1016/S0092-8674(01)00483-4 . PMID   11551509.
  6. "Entrez Gene: MRGPRX2 MAS-related GPR, member X2".
  7. 1 2 Akin C, Elhosni M, Khokar DS (2023). "Mast Cells and Mast Cell disorders". In Rich RR, Fleisher TA, Schroeder HW, Weyand CM, Corry DB, Puck J (eds.). Clinical immunology: principles and practice. Elsevier. p. 563. ISBN   978-0-7020-8165-1.

Further reading