TAS2R43

TAS2R43
Identifiers
Aliases	TAS2R43 , T2R43, T2R52, taste 2 receptor member 43
External IDs	OMIM: 612668 HomoloGene: 128798 GeneCards: TAS2R43
Gene location (Human)
Chr.	Chromosome 12 (human)
End	11,092,313 bp
Gene ontology
Molecular function	• G protein-coupled receptor activity ; • signal transducer activity ; • taste receptor activity ; • bitter taste receptor activity ;
Cellular component	• plasma membrane ; • cell projection ; • motile cilium ; • cilium ; • membrane ; • ciliary membrane ; • integral component of membrane ;
Biological process	• detection of chemical stimulus involved in sensory perception of bitter taste ; • signal transduction ; • response to stimulus ; • sensory perception of taste ; • G protein-coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	259289
	n/a
	ENSG00000255374 ; ENSG00000262612 ; ENSG00000282537
	n/a
	P59537
	n/a
	NM_176884
	n/a
	NP_795365
	n/a
	Wikidata
View/Edit Human

Last updated July 06, 2021

Taste receptor type 2 member 43 is a protein that in humans is encoded by the TAS2R43 gene.^[3]^[4]

Related Research Articles

TAS2R16 is a human gene that encodes for a receptor that may play a role in the perception of bitterness.

Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; varying genotypes of TAS2R38 influence the ability to taste both 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the few taste receptors shown to have this function.

Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene. It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop. Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.

Taste receptor type 2 member 8 is a protein that in humans is encoded by the TAS2R8 gene.

Taste receptor type 2 member 9 is a protein that in humans is encoded by the TAS2R9 gene.

Taste receptor type 2 member 14 is a protein that in humans is encoded by the TAS2R14 gene.

Taste receptor type 2 member 7 is a protein that in humans is encoded by the TAS2R7 gene.

Taste receptor type 1 member 2 is a protein that in humans is encoded by the TAS1R2 gene.

Taste receptor type 1 member 3 is a protein that in humans is encoded by the TAS1R3 gene. The TAS1R3 gene encodes the human homolog of mouse Sac taste receptor, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.

Taste receptor type 2 member 39 is a protein that in humans is encoded by the TAS2R39 gene.

Taste receptor type 2 member 40 is a protein that in humans is encoded by the TAS2R40 gene.

Taste receptor type 2 member 41 is a protein that in humans is encoded by the TAS2R41 gene.

Taste receptor, type 2, member 31, also known as TAS2R31, is a protein which in humans is encoded by the TAS2R31 gene. This bitter taste receptor has been shown to respond to saccharin in vitro.

Taste receptor type 2 member 45 is a protein that in humans is encoded by the TAS2R45 gene.

Taste receptor type 2 member 46 is a protein that in humans is encoded by the TAS2R46 gene.

Taste receptor type 2 member 30 is a protein that in humans is encoded by the TAS2R30 gene.

Taste receptor type 2 member 19 is a protein that in humans is encoded by the TAS2R19 gene. It seems to be involved in the perception of salt and bitter tastes.

Taste receptor type 2 member 20 is a protein that in humans is encoded by the TAS2R20 gene.

Taste receptor type 2 member 50 is a protein that in humans is encoded by the TAS2R50 gene.

Taste receptor type 2 member 60 is a protein that in humans is encoded by the TAS2R60 gene.

References

1 2 3 ENSG00000262612, ENSG00000282537 GRCh38: Ensembl release 89: ENSG00000255374, ENSG00000262612, ENSG00000282537 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. S2CID 20426192.
↑ "Entrez Gene: TAS2R43 taste receptor, type 2, member 43".

Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi: 10.1074/jbc.R100054200 . PMID 11696554.
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982. S2CID 37807140.
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi: 10.1016/S0092-8674(03)00071-0 . PMID 12581520. S2CID 718601.
Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (2003). "Identification and characterization of human taste receptor genes belonging to the TAS2R family". Cytogenet. Genome Res. 98 (1): 45–53. doi:10.1159/000068546. PMID 12584440. S2CID 1542970.
Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi: 10.1093/molbev/msi027 . PMID 15496549.
Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, Meyerhof W (2005). "Bitter taste receptors for saccharin and acesulfame K." J. Neurosci. 24 (45): 10260–5. doi:10.1523/JNEUROSCI.1225-04.2004. PMC 6730199 . PMID 15537898.
Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719 . PMID 15744053.
Behrens M, Bartelt J, Reichling C, Winnig M, Kuhn C, Meyerhof W (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression". J. Biol. Chem. 281 (29): 20650–9. doi: 10.1074/jbc.M513637200 . PMID 16720576.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000262612, ENSG00000282537 GRCh38: Ensembl release 89: ENSG00000255374, ENSG00000262612, ENSG00000282537 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12379855-3] Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. S2CID 20426192.

[entrez-4] "Entrez Gene: TAS2R43 taste receptor, type 2, member 43".

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TAS2R43

Contents

See also

Related Research Articles

References

Further reading