The platelet-activating factor receptor(PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. [5] [6] It is encoded in the human by the PTAFR gene.
The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM] [7] Its pathogenetic role in chronic kidney failure has also been reported recently. [8]
Agonists
Antagonists
Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.
C-X-C motif chemokine 5 is a protein that in humans is encoded by the CXCL5 gene.
Chemokine ligand 7 (CXCL7) is a human gene.
Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene.
Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene.
Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.
P2X purinoceptor 1, also ATP receptor, is a protein that in humans is encoded by the P2RX1 gene.
P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.
Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.
The alpha-1B adrenergic receptor (α1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. The crystal structure of the α1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.
The alpha-1D adrenergic receptor, also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.
Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene. LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).
Probable G-protein coupled receptor 135 is a protein that in humans is encoded by the GPR135 gene.
Lysophosphatidic acid receptor 3 also known as LPA3 is a protein that in humans is encoded by the LPAR3 gene. LPA3 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).
Proto-oncogene tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene.
Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.
Interleukin 9 receptor (IL9R) also known as CD129 is a type I cytokine receptor. IL9R also denotes its human gene.
Glycoprotein V (platelet) (GP5) also known as CD42d (Cluster of Differentiation 42d), is a human gene.
Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene.
Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene. It is one of several PAF acetylhydrolases.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.