The platelet-activating factor receptor(PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. [5] [6] It is encoded in the human by the PTAFR gene.
The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM] [7] Its pathogenetic role in chronic kidney failure has also been reported recently. [8]
Agonists
Antagonists
This article incorporates text from the United States National Library of Medicine, which is in the public domain.