CELSR1

Last updated
CELSR1
Identifiers
Aliases CELSR1 , CDHF9, FMI2, HFMI2, ME2, ADGRC1, cadherin EGF LAG seven-pass G-type receptor 1, LMPHM9
External IDs OMIM: 604523; MGI: 1100883; HomoloGene: 7665; GeneCards: CELSR1; OMA:CELSR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014246
NM_001378328

NM_009886

RefSeq (protein)

NP_055061
NP_001365257

NP_034016

Location (UCSC) Chr 22: 46.36 – 46.54 Mb Chr 15: 85.78 – 85.92 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene. [5] [6]

Contents

Function

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin G-like domains in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000075275 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016028 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM, Little PF (Nov 1997). "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter" (PDF). Genomics. 45 (1): 97–104. doi:10.1006/geno.1997.4892. PMID   9339365. Archived (PDF) from the original on 2019-02-18. Retrieved 2019-09-17.
  6. 1 2 "Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)". Archived from the original on 2024-05-02. Retrieved 2017-08-30.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.