Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene. [5] [6]
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin G-like domains in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [6]
Flamingo is a member of the adhesion-GPCR family of proteins. Flamingo has sequence homology to cadherins and G protein-coupled receptors (GPCR). Flamingo was originally identified as a Drosophila protein involved in planar cell polarity. Mammals have three flamingo homologs, CELSR1, CELSR2, CELSR3. In mice all three have distinct expression patterns in the brain.
Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.
Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.
Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene.
Protocadherin gamma-C3 is a protein that in humans is encoded by the PCDHGC3 gene.
Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.
Protocadherin beta-13 is a protein that in humans is encoded by the PCDHB13 gene.
Protocadherin beta-5 is a protein that in humans is encoded by the PCDHB5 gene.
Protocadherin-17 is a protein that in humans is encoded by the PCDH17 gene.
Protocadherin beta-11 is a protein that in humans is encoded by the PCDHB11 gene.
Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene.
Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene.
Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.
Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene.
Protocadherin alpha-5 is a protein that in humans is encoded by the PCDHA5 gene.
Protocadherin gamma-A12 is a protein that in humans is encoded by the PCDHGA12 gene.
Protocadherin gamma-B7 is a protein that in humans is encoded by the PCDHGB7 gene.
Protocadherin beta-12 is a protein that in humans is encoded by the PCDHB12 gene.
Protocadherin alpha-C2 is a protein that in humans is encoded by the PCDHAC2 gene.
Protocadherin alpha-1 is a protein that in humans is encoded by the PCDHA1 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.