CELSR1

Last updated
CELSR1
Identifiers
Aliases CELSR1 , CDHF9, FMI2, HFMI2, ME2, ADGRC1, cadherin EGF LAG seven-pass G-type receptor 1, LMPHM9
External IDs OMIM: 604523 MGI: 1100883 HomoloGene: 7665 GeneCards: CELSR1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014246
NM_001378328

NM_009886

RefSeq (protein)

NP_055061
NP_001365257

NP_034016

Location (UCSC) Chr 22: 46.36 – 46.54 Mb Chr 15: 85.78 – 85.92 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene. [5] [6]

Contents

Function

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin G-like domains in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [6]

See also

Related Research Articles

Flamingo is a member of the adhesion-GPCR family of proteins. Flamingo has sequence homology to cadherins and G protein-coupled receptors (GPCR). Flamingo was originally identified as a Drosophila protein involved in planar cell polarity. Mammals have three flamingo homologs, CELSR1, CELSR2, CELSR3. In mice all three have distinct expression patterns in the brain.

<span class="mw-page-title-main">CELSR3</span> Protein-coding gene in the species Homo sapiens

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

<span class="mw-page-title-main">CELSR2</span> Protein-coding gene in the species Homo sapiens

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.

<span class="mw-page-title-main">PCDH1</span>

Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene.

<span class="mw-page-title-main">PCDHGC3</span>

Protocadherin gamma-C3 is a protein that in humans is encoded by the PCDHGC3 gene.

<span class="mw-page-title-main">PCDH8</span>

Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.

<span class="mw-page-title-main">PCDHB13</span>

Protocadherin beta-13 is a protein that in humans is encoded by the PCDHB13 gene.

<span class="mw-page-title-main">PCDHB5</span>

Protocadherin beta-5 is a protein that in humans is encoded by the PCDHB5 gene.

<span class="mw-page-title-main">PCDH17</span>

Protocadherin-17 is a protein that in humans is encoded by the PCDH17 gene.

<span class="mw-page-title-main">PCDHB11</span>

Protocadherin beta-11 is a protein that in humans is encoded by the PCDHB11 gene.

<span class="mw-page-title-main">PCDHA12</span>

Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene.

<span class="mw-page-title-main">PCDHA6</span>

Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene.

<span class="mw-page-title-main">PCDHA4</span>

Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.

<span class="mw-page-title-main">PCDH12</span>

Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene.

<span class="mw-page-title-main">PCDHA5</span>

Protocadherin alpha-5 is a protein that in humans is encoded by the PCDHA5 gene.

<span class="mw-page-title-main">PCDHGA12</span>

Protocadherin gamma-A12 is a protein that in humans is encoded by the PCDHGA12 gene.

<span class="mw-page-title-main">PCDHGB7</span>

Protocadherin gamma-B7 is a protein that in humans is encoded by the PCDHGB7 gene.

<span class="mw-page-title-main">PCDHB12</span> Protein-coding gene in humans

Protocadherin beta-12 is a protein that in humans is encoded by the PCDHB12 gene.

<span class="mw-page-title-main">PCDHAC2</span>

Protocadherin alpha-C2 is a protein that in humans is encoded by the PCDHAC2 gene.

<span class="mw-page-title-main">Protocadherin alpha 1</span>

Protocadherin alpha-1 is a protein that in humans is encoded by the PCDHA1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000075275 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016028 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM, Little PF (Nov 1997). "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter" (PDF). Genomics. 45 (1): 97–104. doi:10.1006/geno.1997.4892. PMID   9339365.
  6. 1 2 "Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.