Pancreatic polypeptide receptor 1

NPY4R
Identifiers
Aliases	NPY4R , NPY4-R, PP1, PPYR1, Y4, Pancreatic polypeptide receptor 1, neuropeptide Y receptor Y4
External IDs	OMIM: 601790; MGI: 105374; HomoloGene: 116086; GeneCards: NPY4R; OMA:NPY4R - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q11.22 Start 46,461,099 bp [1] End 46,465,958 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 B|14 20.8 cM Start 33,865,949 bp [2] End 33,874,446 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum transverse colon muscle layer of sigmoid colon duodenum mucosa of transverse colon smooth muscle tissue skin of abdomen skin of leg appendix stomach Top expressed in embryo lip urinary bladder digastric muscle stomach duodenum lumbar spinal ganglion jejunum ileum submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide Y receptor activity G protein-coupled receptor activity signal transducer activity pancreatic polypeptide receptor activity peptide hormone binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process signal transduction neuropeptide signaling pathway chemical synaptic transmission G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5540 19065 Ensembl ENSG00000204174 ENSMUSG00000048337 UniProt P0DQD5 P50391 Q61041 RefSeq (mRNA) NM_001278794 NM_005972 NM_008919 RefSeq (protein) NP_001265724 NP_001265723 NP_005963 NP_001265724 NP_032945 Location (UCSC) Chr 10: 46.46 – 46.47 Mb Chr 14: 33.87 – 33.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene. ^{[5] [6] [7]}

Selective Ligands

Agonists

• Pancreatic polypeptide
• Neuropeptide Y (endogenous agonist, non subtype selective)
• Peptide YY
• GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Antagonists

• UR-AK49 ^[8]

See also

• Neuropeptide Y receptor

References

1. GRCh38: Ensembl release 89: ENSG00000204174 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048337 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (December 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–290. doi: 10.1006/geno.1997.5024 . PMID   9417917.
6. "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".
7. Al-hussaniy HA, AL-Biati HA (2022-12-02). "The Role of Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio in Obesogenesis: Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio". Medical and Pharmaceutical Journal. 1 (2). doi: 10.55940/medphar20227 . ISSN   2957-6067.
8. Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research. 27 (4): 217–233. doi:10.1080/10799890701505206. PMID   17885919. S2CID   26579625.

External links

• "Neuropeptide Y Receptors: Y₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

Further reading

• Keire DA, Bowers CW, Solomon TE, Reeve JR (February 2002). "Structure and receptor binding of PYY analogs". Peptides. 23 (2): 305–321. doi:10.1016/S0196-9781(01)00602-7. PMID   11825645. S2CID   7082920.
• Balasubramaniam A (April 2002). "Clinical potentials of neuropeptide Y family of hormones". American Journal of Surgery. 183 (4): 430–434. doi:10.1016/S0002-9610(02)00803-6. PMID   11975932.
• Parker E, Van Heek M, Stamford A (April 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–187. doi:10.1016/S0014-2999(02)01427-9. PMID   12007534.
• Benaim G, Villalobo A (August 2002). "Phosphorylation of calmodulin. Functional implications". European Journal of Biochemistry. 269 (15): 3619–3631. doi:10.1046/j.1432-1033.2002.03038.x. hdl: 10261/79981 . PMID   12153558.
• Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, et al. (December 1995). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY". The Journal of Biological Chemistry. 270 (49): 29123–29128. doi: 10.1074/jbc.270.49.29123 . PMID   7493937.
• Bard JA, Walker MW, Branchek TA, Weinshank RL (November 1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY". The Journal of Biological Chemistry. 270 (45): 26762–26765. doi: 10.1074/jbc.270.45.26762 . PMID   7592911.
• Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W (May 1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4661–4665. Bibcode:1996PNAS...93.4661Y. doi: 10.1073/pnas.93.10.4661 . PMC   39335 . PMID   8643460.
• Kawabe T, Muslin AJ, Korsmeyer SJ (January 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–458. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. PMID   9009195. S2CID   608633.
• Darby K, Eyre HJ, Lapsys N, Copeland NG, Gilbert DJ, Couzens M, et al. (December 1997). "Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14". Genomics. 46 (3): 513–515. doi:10.1006/geno.1997.5071. PMID   9441761.
• Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P (April 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14): 4365–4373. doi:10.1021/bi982900m. PMID   10194355.
• Smith FD, Oxford GS, Milgram SL (July 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". The Journal of Biological Chemistry. 274 (28): 19894–19900. doi: 10.1074/jbc.274.28.19894 . PMID   10391935.
• Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. 101 (4): 365–376. doi: 10.1016/S0092-8674(00)80847-8 . PMID   10830164. S2CID   6496567.
• Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S (October 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Molecular and Cellular Biology. 21 (20): 6841–6850. doi:10.1128/MCB.21.20.6841-6850.2001. PMC   99861 . PMID   11564868.
• Cavadas C, Silva AP, Mosimann F, Cotrim MD, Ribeiro CA, Brunner HR, Grouzmann E (December 2001). "NPY regulates catecholamine secretion from human adrenal chromaffin cells". The Journal of Clinical Endocrinology and Metabolism. 86 (12): 5956–5963. doi: 10.1210/jcem.86.12.8091 . hdl: 10316/12627 . PMID   11739470.
• Cox HM, Tough IR (March 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–1512. doi:10.1038/sj.bjp.0704604. PMC   1573267 . PMID   11906964.
• Wu DY, Tkachuck DC, Roberson RS, Schubach WH (August 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". The Journal of Biological Chemistry. 277 (31): 27706–27715. doi: 10.1074/jbc.M200955200 . PMID   12016208.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.