GPR26

GPR26
Identifiers
Aliases	GPR26 , G protein-coupled receptor 26
External IDs	OMIM: 604847; MGI: 2441758; HomoloGene: 17764; GeneCards: GPR26; OMA:GPR26 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q26.13 Start 123,666,355 bp [1] End 123,697,399 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 131,568,189 bp [2] End 131,596,134 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 pars compacta pars reticulata tendon of biceps brachii middle temporal gyrus Brodmann area 46 buccal mucosa cell myocardium myocardium of left ventricle Top expressed in superior frontal gyrus primary visual cortex lumbar subsegment of spinal cord dentate gyrus of hippocampal formation granule cell islands of Calleja amygdalohippocampal area medial septal nucleus dorsal cochlear nucleus cortical amygdaloid nucleus paraventricular nucleus of thalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity G protein-coupled receptor activity Cellular component plasma membrane membrane integral component of membrane intracellular anatomical structure Biological process adenylate cyclase-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2849 233919 Ensembl ENSG00000154478 ENSMUSG00000040125 UniProt Q8NDV2 Q8BZA7 RefSeq (mRNA) NM_153442 NM_173410 RefSeq (protein) NP_703143 NP_775586 Location (UCSC) Chr 10: 123.67 – 123.7 Mb Chr 7: 131.57 – 131.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 26 is a protein that in humans is encoded by the GPR26 gene. ^[5] GPR26 expression is found to peak perinatally, when the visual system is first challenged, and contains a 53 kb LD-block enriched for association with introgressed Neanderthal-derived SNPs. Additionally, it is known to form oligomeric structures with the 5-HT1a receptor. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000154478 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040125 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR26 G protein-coupled receptor 26".
6. Gregory MD, Kippenhan JS, Eisenberg DP, Kohn PD, Dickinson D, Mattay VS, et al. (July 2017). "Neanderthal-Derived Genetic Variation Shapes Modern Human Cranium and Brain". Scientific Reports. 7 (1): 6308. Bibcode:2017NatSR...7.6308G. doi:10.1038/s41598-017-06587-0. PMC   5524936 . PMID   28740249.

Further reading

• Adams MD, Soares MB, Kerlavage AR, Fields C, Venter JC (August 1993). "Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library". Nature Genetics. 4 (4): 373–380. doi:10.1038/ng0893-373. PMID   8401585. S2CID   12612300.
• Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, et al. (February 2000). "Cloning and characterization of additional members of the G protein-coupled receptor family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (3): 311–323. doi:10.1016/s0167-4781(99)00241-9. PMID   10684976.
• Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, et al. (May 2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". The Journal of Biological Chemistry. 277 (18): 15482–15485. doi: 10.1074/jbc.M201539200 . PMID   11854302.