VIPR1

Last updated

VIPR1
PDB 1of2 EBI.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases VIPR1 , HVR1, II, PACAP-R-2, PACAP-R2, RDC1, V1RG, VAPC1, VIP-R-1, VIPR, VIRG, VPAC1, VPAC1R, VPCAP1R, vasoactive intestinal peptide receptor 1
External IDs OMIM: 192321; MGI: 109272; HomoloGene: 3399; GeneCards: VIPR1; OMA:VIPR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001251882
NM_001251883
NM_001251884
NM_001251885
NM_004624

Contents

NM_011703

RefSeq (protein)

NP_001238811
NP_001238812
NP_001238813
NP_001238814
NP_004615

NP_035833

Location (UCSC) Chr 3: 42.49 – 42.54 Mb Chr 9: 121.47 – 121.5 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Vasoactive intestinal polypeptide receptor 1 also known as VPAC1, is a protein, that in humans is encoded by the VIPR1 gene. [5] VPAC1 is expressed in the brain (cerebral cortex, hippocampus, amygdala), lung, prostate, peripheral blood leukocytes, liver, small intestine, heart, spleen, placenta, kidney, thymus and testis. [6] [7] [8]

Function

VPAC1 is a receptor for vasoactive intestinal peptide (VIP), a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [5]

VIP acts in an autocrine fashion via VPAC11 to inhibit megakaryocyte proliferation and induce proplatelet formation. [9] [10]

Clinical significance

Patients with idiopathic achalasia show a significant difference in the distribution of SNPs affecting VIPR1. [11]

VIP and PACAP levels were decreased in anterior vaginal wall of stress urinary incontinence and pelvic organ prolapse patients, they may participate in the pathophysiology of these diseases. [12]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000114812 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032528 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: VIPR1 vasoactive intestinal peptide receptor 1".
  6. Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S (Apr 1992). "Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide". Neuron. 8 (4): 811–9. doi:10.1016/0896-6273(92)90101-I. PMID   1314625. S2CID   43589458.
  7. Usdin TB, Bonner TI, Mezey E (Dec 1994). "Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions". Endocrinology. 135 (6): 2662–80. doi:10.1210/endo.135.6.7988457. PMID   7988457.
  8. Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ (Mar 1995). "Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene". Proceedings of the National Academy of Sciences of the United States of America. 92 (7): 2939–43. Bibcode:1995PNAS...92.2939S. doi: 10.1073/pnas.92.7.2939 . PMC   42334 . PMID   7708752.
  9. Nam C, Case AJ, Hostager BS, O'Dorisio MS (Feb 2009). "The role of vasoactive intestinal peptide (VIP) in megakaryocyte proliferation". Journal of Molecular Neuroscience. 37 (2): 160–7. doi:10.1007/s12031-008-9119-x. PMID   18663606. S2CID   2030939.
  10. Freson K, Peeters K, De Vos R, Wittevrongel C, Thys C, Hoylaerts MF, Vermylen J, Van Geet C (Feb 2008). "PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications". Blood. 111 (4): 1885–93. doi:10.1182/blood-2007-06-098558. PMID   18000164. S2CID   24342247.
  11. Paladini F, Cocco E, Cascino I, Belfiore F, Badiali D, Piretta L, Alghisi F, Anzini F, Fiorillo MT, Corazziari E, Sorrentino R (Jun 2009). "Age-dependent association of idiopathic achalasia with vasoactive intestinal peptide receptor 1 gene". Neurogastroenterology and Motility. 21 (6): 597–602. doi:10.1111/j.1365-2982.2009.01284.x. PMID   19309439. S2CID   24081228.
  12. Hong X, Huang L, Song Y (Aug 2008). "Role of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide in the vaginal wall of women with stress urinary incontinence and pelvic organ prolapse". International Urogynecology Journal and Pelvic Floor Dysfunction. 19 (8): 1151–7. doi:10.1007/s00192-008-0585-z. PMID   18351280. S2CID   2482642.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.