Brain-specific angiogenesis inhibitor 2

Last updated
ADGRB2
Identifiers
Aliases ADGRB2 , BAI2, adhesion G protein-coupled receptor B2
External IDs OMIM: 602683 MGI: 2451244 HomoloGene: 1288 GeneCards: ADGRB2
Gene location (Human)
Ideogram human chromosome 1.svg
Chr. Chromosome 1 (human) [1]
Human chromosome 1 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 1p35.2Start31,727,117 bp [1]
End31,764,893 bp [1]
RNA expression pattern
PBB GE BAI2 204966 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001294335
NM_001294336
NM_001364857

RefSeq (protein)

NP_001281264
NP_001281265
NP_001351786

NP_001186625
NP_001277643
NP_001277644
NP_775094

Location (UCSC) Chr 1: 31.73 – 31.76 Mb Chr 4: 129.98 – 130.02 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene. [5] [6] It is a member of the adhesion-GPCR family of receptors. [7]

Contents

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. [6]

Related Research Articles

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G protein-coupled receptor 98, also known as GPR98 or VLGR1, is a protein that in humans is encoded by the GPR98 gene. Several alternatively spliced transcripts have been described.

Brain-specific angiogenesis inhibitor 1 protein-coding gene in the species Homo sapiens

Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene. It is a member of the adhesion-GPCR family of receptors.

Brain-specific angiogenesis inhibitor 3 protein-coding gene in the species Homo sapiens

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.

CELSR2 protein-coding gene in the species Homo sapiens

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Brain-specific angiogenesis inhibitors are G-protein coupled receptors belonging to the class B secretin subfamily. Members include:

Latrophilin 1 protein-coding gene in the species Homo sapiens

Latrophilin 1 is a protein that in humans is encoded by the ADGRL1 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Latrophilin 3 protein-coding gene in the species Homo sapiens

Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene.

GPR124 protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR126 protein-coding gene in the species Homo sapiens

G protein-coupled receptor 126 also known as VIGR and DREG is a protein encoded by the ADGRG6 gene. GPR126 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR123 protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene. It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR110 protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR133 protein-coding gene in the species Homo sapiens

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GPR144 protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 144 is a protein that in humans is encoded by the GPR144 gene. This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterised by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR83 protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 83 is a protein that in humans is encoded by the GPR83 gene.

Latrophilin 2 protein-coding gene in the species Homo sapiens

Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.

OR1D2 protein-coding gene in the species Homo sapiens

Olfactory receptor 1D2 is a protein that in humans is encoded by the OR1D2 gene.

BAIAP2 protein-coding gene in the species Homo sapiens

Brain-specific angiogenesis inhibitor 1-associated protein 2 is a protein that in humans is encoded by the BAIAP2 gene.

NRCAM protein-coding gene in the species Homo sapiens

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.

ANGPT4 protein-coding gene in the species Homo sapiens

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.

BAIAP3 protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000121753 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028782 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet. 79 (1–2): 103–8. doi:10.1159/000134693. PMID   9533023.
  6. 1 2 "Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2".
  7. Stacey, edited by Simon Yona, Martin (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN   9781441979124.CS1 maint: extra text: authors list (link)

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.