Brain-specific angiogenesis inhibitor 2

"BAI2" redirects here. For the banking file format, see BAI (file format).

ADGRB2
Identifiers
Aliases	ADGRB2 , BAI2, adhesion G protein-coupled receptor B2
External IDs	OMIM: 602683; MGI: 2451244; HomoloGene: 1288; GeneCards: ADGRB2; OMA:ADGRB2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p35.2 Start 31,727,117 bp [1] End 31,764,893 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.2 Start 129,878,663 bp [2] End 129,916,426 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe prefrontal cortex anterior cingulate cortex ganglionic eminence dorsolateral prefrontal cortex nucleus accumbens caudate nucleus Brodmann area 9 Brodmann area 10 amygdala Top expressed in primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell subiculum hippocampus proper prefrontal cortex piriform cortex olfactory tubercle primary motor cortex cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity signal transducer activity G protein-coupled receptor activity protein binding Cellular component integral component of membrane membrane plasma membrane centrosome integral component of plasma membrane Biological process negative regulation of angiogenesis cell surface receptor signaling pathway peripheral nervous system development signal transduction positive regulation of synapse assembly G protein-coupled receptor signaling pathway calcineurin-NFAT signaling cascade adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 576 230775 Ensembl ENSG00000121753 ENSMUSG00000028782 UniProt O60241 Q8CGM1 RefSeq (mRNA) NM_001294335 NM_001294336 NM_001364857 NM_001199696 NM_001290714 NM_001290715 NM_173071 NM_001377056 NM_001377057 NM_001377058 RefSeq (protein) NP_001281264 NP_001281265 NP_001351786 NP_001186625 NP_001277643 NP_001277644 NP_775094 NP_001363985 NP_001363986 NP_001363987 Location (UCSC) Chr 1: 31.73 – 31.76 Mb Chr 4: 129.88 – 129.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene. ^{[5] [6]} It is a member of the adhesion-GPCR family of receptors. ^[7]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000121753 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028782 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet. 79 (1–2): 103–8. doi:10.1159/000134693. PMID   9533023.
6. "Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2".
7. Stacey, edited by Simon Yona, Martin (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN   9781441979124.{{cite book}}: |first= has generic name (help)

External links

• Human ADGRB2 genome location and ADGRB2 gene details page in the UCSC Genome Browser .

Further reading

• Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". J. Biol. Chem. 275 (42): 32387–90. doi: 10.1074/jbc.C000490200 . PMID   10964907.
• Kee HJ, Koh JT, Kim MY, et al. (2002). "Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis". J. Cereb. Blood Flow Metab. 22 (9): 1054–67. doi: 10.1097/00004647-200209000-00003 . PMID   12218411.
• Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell Sci. 116 (Pt 3): 453–61. doi: 10.1242/jcs.00243 . PMID   12508107.
• Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell. Proteomics. 1 (12): 947–55. doi: 10.1074/mcp.M200066-MCP200 . PMID   12543931.
• Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID   14697242.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID   15203201.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.