MRGPRX4

MRGPRX4
Identifiers
Aliases	MRGPRX4 , GPCR, MRGX4, SNSR6, MAS related GPR family member X4
External IDs	OMIM: 607230; MGI: 3033139; HomoloGene: 86184; GeneCards: MRGPRX4; OMA:MRGPRX4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.1 Start 18,172,837 bp [1] End 18,174,280 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B4 Start 47,670,719 bp [2] End 47,677,345 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of hip olfactory zone of nasal mucosa Top expressed in lip neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity G protein-coupled receptor activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117196 404242 Ensembl ENSG00000179817 ENSMUSG00000070552 UniProt Q96LA9 Q8CIP3 RefSeq (mRNA) NM_054032 NM_207540 RefSeq (protein) NP_473373 NP_997423 Location (UCSC) Chr 11: 18.17 – 18.17 Mb Chr 7: 47.67 – 47.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mas-related G-protein coupled receptor member X4 is a protein that in humans is encoded by the MRGPRX4 gene. ^{[5] [6]}

Ligands

Agonists

• PSB-22040

Antagonists and inverse agonists

• Nelremagpran

See also

• MAS1 oncogene

References

1. GRCh38: Ensembl release 89: ENSG00000179817 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070552 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–32. doi: 10.1016/S0092-8674(01)00483-4 . PMID   11551509. S2CID   14119088.
6. "Entrez Gene: MRGPRX4 MAS-related GPR, member X4".

Further reading

• Lembo PM, Grazzini E, Groblewski T, et al. (2002). "Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs". Nat. Neurosci. 5 (3): 201–9. doi:10.1038/nn815. PMID   11850634. S2CID   42544746.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.