PSB-22040

Last updated
PSB-22040
PSB-22040 structure.png
Identifiers
  • 4-[8-[2-(3-methoxyphenyl)ethyl]-7-methyl-2,6-dioxo-1-prop-2-ynylpurin-3-yl]butylphosphonic acid
CAS Number
PubChem CID
Chemical and physical data
Formula C22H27N4O6P
Molar mass 474.454 g·mol−1
3D model (JSmol)
  • CN1C(=NC2=C1C(=O)N(C(=O)N2CCCCP(=O)(O)O)CC#C)CCC3=CC(=CC=C3)OC
  • InChI=1S/C22H27N4O6P/c1-4-12-26-21(27)19-20(25(22(26)28)13-5-6-14-33(29,30)31)23-18(24(19)2)11-10-16-8-7-9-17(15-16)32-3/h1,7-9,15H,5-6,10-14H2,2-3H3,(H2,29,30,31)
  • Key:AZZJGHGFQWAMCB-UHFFFAOYSA-N

PSB-22040 is an experimental drug that acts as a potent and selective agonist of the MAS-related Gq protein-coupled receptor X4 (MRGPRX4). This receptor is poorly characterised but is thought to be involved in immune system function, and development of selective ligands is essential for researching its role in the body. [1]

References

  1. ↑ Marx D, Alnouri MW, Clemens S, Gedschold R, Riedel Y, Al Hamwi G, Pillaiyar T, Hockemeyer J, Namasivayam V, Müller CE. Discovery of Potent Agonists for the Predominant Variant of the Orphan MAS-Related G Protein-Coupled Receptor X4 (MRGPRX4). J Med Chem. 2023 Dec 14;66(23):15674-15698. doi : 10.1021/acs.jmedchem.3c01013 PMID   37967029


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