Nelremagpran

Last updated
Nelremagpran
Nelremagpran.svg
Identifiers
  • 3-[[2-chloro-4-(trifluoromethyl)phenoxy]methyl]-2-fluorobenzoic acid
CAS Number
PubChem CID
Chemical and physical data
Formula C15H9ClF4O3
Molar mass 348.68 g·mol−1
3D model (JSmol)
  • C1=CC(=C(C(=C1)C(=O)O)F)COC2=C(C=C(C=C2)C(F)(F)F)Cl
  • InChI=1S/C15H9ClF4O3/c16-11-6-9(15(18,19)20)4-5-12(11)23-7-8-2-1-3-10(13(8)17)14(21)22/h1-6H,7H2,(H,21,22)
  • Key:TWOXPNAILYKJPT-UHFFFAOYSA-N

Nelremagpran is an experimental drug that acts as a potent and selective antagonist (or possibly inverse agonist) of the MAS-related Gq protein-coupled receptor X4 (MRGPRX4). It has antiinflammatory effects in animal studies. This receptor is poorly characterised but is thought to be involved in immune system function, and development of selective ligands is essential for researching its role in the body. [1] [2]

References

  1. ↑ WO 2020/198537,Yeager A, Selfridge B, Sainz M, Martinborough E, Boehm M, Huang,"Modulators of mas-related G-protein receptor x4 and related products and methods.",published 1 October 2020, assigned to Escient Pharmaceuticals, Inc.
  2. ↑ "International Nonproprietary Names for Pharmaceutical Substances (INN)" (PDF). WHO Drug Information. 38 (4). 2024.


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.