GPR52

GPR52
Identifiers
Aliases	GPR52 , G protein-coupled receptor 52
External IDs	OMIM: 604106 MGI: 3643278 HomoloGene: 74561 GeneCards: GPR52
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q25.1 Start 174,447,964 bp [1] End 174,449,545 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H2.1 Start 160,403,908 bp [2] End 160,405,544 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells nucleus accumbens prefrontal cortex putamen caudate nucleus Achilles tendon Brodmann area 9 thymus anterior pituitary hypothalamus Top expressed in superior frontal gyrus hypothalamus hippocampus proper duodenum ileum uterus cerebellar cortex jejunum liver mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function dopamine neurotransmitter receptor activity, coupled via Gs signal transducer activity G protein-coupled receptor activity G protein-coupled photoreceptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway signal transduction dopamine receptor signaling pathway locomotory behavior phototransduction detection of visible light cellular response to light stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9293 620246 Ensembl ENSG00000203737 ENSMUSG00000118401 UniProt Q9Y2T5 P0C5J4 RefSeq (mRNA) NM_005684 NM_001146330 NM_001368668 RefSeq (protein) NP_005675 NP_001139802 NP_001355597 Location (UCSC) Chr 1: 174.45 – 174.45 Mb Chr 1: 160.4 – 160.41 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 52 is a protein that in humans is encoded by the GPR52 gene. ^{[5] [6]}

Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM] ^[6]

Cannabidiol, CBD, and O-1918 are Inverse agonist at GPR52 ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000203737 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000118401 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF (Mar 1999). "Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain". Brain Res Mol Brain Res. 64 (2): 193–8. doi:10.1016/S0169-328X(98)00277-0. PMID   9931487.
6. "Entrez Gene: GPR52 G protein-coupled receptor 52".
7. Stott LA, Brighton CA, Brown J, Mould R, Bennett KA, Newman R, Currinn H, Autore F, Higueruelo AP, Tehan BG, MacSweeney C (2021-06-01). "Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918". Heliyon. 7 (6): e07201. Bibcode:2021Heliy...707201S. doi:10.1016/j.heliyon.2021.e07201. ISSN   2405-8440. PMC   8219759 . PMID   34189291.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.