GPR42

GPR42
Identifiers
Aliases	GPR42 , FFAR1L, FFAR3L, GPR41L, GPR42P, G protein-coupled receptor 42 (gene/pseudogene), G protein-coupled receptor 42
External IDs	OMIM: 603822; MGI: 2685324; GeneCards: GPR42; OMA:GPR42 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.12 Start 35,371,068 bp [1] End 35,372,962 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B1 Start 30,553,755 bp [2] End 30,555,603 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood muscle layer of sigmoid colon muscle of thigh islet of Langerhans appendix subcutaneous adipose tissue urinary bladder lactiferous gland gallbladder muscle tissue Top expressed in islet of Langerhans embryo blastocyst nerve trunk proximal tubule autonomic nervous system right kidney sympathetic nervous system sympathetic ganglion duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2866 233080 Ensembl ENSG00000126251 ENSMUSG00000019429 UniProt O15529 Q3UFD7 RefSeq (mRNA) NM_005305 NM_001348195 NM_001033316 RefSeq (protein) NP_001335124 NP_001028488 Location (UCSC) Chr 19: 35.37 – 35.37 Mb Chr 7: 30.55 – 30.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Putative G-protein coupled receptor 42 (previously termed FFAR1L, FFAR3L, GPR41L, and GPR42P) is a protein that in humans is encoded by the GPR42 gene. ^{[5] [6]} The human GPR gene is located at the same site as the human FFAR1, FFAR, and FFAR3 genes, i.e., on the long (i.e., "q") arm of chromosome 19 at position 23.33 (notated as 19q23.33). This gene appears to be a segmental duplication of the FFAR3 gene. The human GPR42 gene codes for several proteins with a FFAR3-like structure but their expression in various cell types and tissues as well as their activities and functions have not yet been clearly defined in any scientific publication followed by PubMed as of 2023. ^{[7] [8] [9] [10]}

See also

• Free fatty acid receptors
• Free fatty acid receptor 3

References

1. GRCh38: Ensembl release 89: ENSG00000126251 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019429 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sawzdargo M, George SR, Nguyen T, Xu S, Kolakowski LF, O'Dowd BF (Nov 1997). "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1". Biochem Biophys Res Commun. 239 (2): 543–7. doi:10.1006/bbrc.1997.7513. PMID   9344866.
6. "Entrez Gene: GPR42 G protein-coupled receptor 42".
7. Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ (March 2003). "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids". The Journal of Biological Chemistry. 278 (13): 11312–9. doi: 10.1074/jbc.M211609200 . PMID   12496283.
8. Liaw CW, Connolly DT (November 2009). "Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42". DNA and Cell Biology. 28 (11): 555–60. doi:10.1089/dna.2009.0916. PMID   19630535.
9. Puhl HL, Won YJ, Lu VB, Ikeda SR (August 2015). "Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed". Scientific Reports. 5: 12880. Bibcode:2015NatSR...512880P. doi:10.1038/srep12880. PMC   4531286 . PMID   26260360.
10. Pluznick JL (April 2017). "Microbial Short-Chain Fatty Acids and Blood Pressure Regulation". Current Hypertension Reports. 19 (4): 25. doi:10.1007/s11906-017-0722-5. PMC   5584783 . PMID   28315048.

Further reading

• Brown AJ, Jupe S, Briscoe CP (2005). "A family of fatty acid binding receptors". DNA Cell Biol. 24 (1): 54–61. doi:10.1089/dna.2005.24.54. PMID   15684720.
• Brown AJ, Goldsworthy SM, Barnes AA, et al. (2003). "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids". J. Biol. Chem. 278 (13): 11312–9. doi: 10.1074/jbc.M211609200 . PMID   12496283.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.

External links

• "Free Fatty Acid Receptors: GPR42". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.