Bombesin-like receptor 3

Last updated
BRS3
Identifiers
Aliases BRS3 , BB3, bombesin like receptor 3, BB3R, bombesin receptor subtype 3, BBR3
External IDs OMIM: 300107; MGI: 1100501; HomoloGene: 1307; GeneCards: BRS3; OMA:BRS3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001727

NM_009766

RefSeq (protein)

NP_001718

NP_033896

Location (UCSC) Chr X: 136.49 – 136.49 Mb Chr X: 56.09 – 56.09 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The bombesin receptor subtype 3 also known as BRS-3 or BB3 [5] is a protein which in humans is encoded by the BRS3 gene. [6] [7]

Contents

Function

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article). [7] [8]

BB3 is a G protein-coupled receptor. [6] BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor. [6] [9] [10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000102239 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031130 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Bombesin Receptors: BB3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
  6. 1 2 3 Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. doi: 10.1016/S0021-9258(18)53415-3 . PMID   8383682.
  7. 1 2 Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1–2): 165–72. doi:10.1016/S0006-8993(97)00380-6. PMID   9262170. S2CID   1012779.
  8. "Entrez Gene: BRS3 bombesin-like receptor 3".
  9. Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors". J. Biol. Chem. 272 (41): 26062–26071. doi: 10.1074/jbc.272.41.26062 . PMID   9325344.
  10. Jensen RT, Battey JF, Spindel ER, Benya RV (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states". Pharmacol. Rev. 60 (1): 1–42. doi:10.1124/pr.107.07108. PMC   2517428 . PMID   18055507.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.