Pyroglutamylated RFamide peptide receptor

QRFPR
Identifiers
Aliases	QRFPR , AQ27, GPR103, SP9155, pyroglutamylated RFamide peptide receptor
External IDs	OMIM: 606925; MGI: 2677633; HomoloGene: 18865; GeneCards: QRFPR; OMA:QRFPR - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q27 Start 121,328,642 bp [1] End 121,381,059 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 B Start 36,233,573 bp [2] End 36,276,462 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad renal cortex left ventricle prefrontal cortex primary visual cortex hypothalamus right auricle of heart apex of heart superior frontal gyrus bone marrow cells Top expressed in ventromedial nucleus piriform cortex embryo tail of embryo neural layer of retina lumbar subsegment of spinal cord temporal lobe ventricular zone olfactory bulb paraventricular nucleus of hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function neuropeptide Y receptor activity peptide binding G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process cellular response to hormone stimulus neuropeptide signaling pathway signal transduction response to peptide G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84109 229214 Ensembl ENSG00000186867 ENSMUSG00000058400 UniProt Q96P65 P83861 RefSeq (mRNA) NM_198179 NM_198192 RefSeq (protein) NP_937822 NP_937835 Location (UCSC) Chr 4: 121.33 – 121.38 Mb Chr 3: 36.23 – 36.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene. ^{[5] [6]}

Function

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. ^[5]

A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. ^[7] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000186867 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058400 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR103 G protein-coupled receptor 103".
6. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID   11574155.
7. Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi: 10.1074/jbc.M302945200 . PMID   12714592.
8. Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi: 10.1074/jbc.M305270200 . PMID   12960173.

Further reading

• Lee DK, Nguyen T, Lynch KR, et al. (2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID   11574155.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jiang Y, Luo L, Gustafson EL, et al. (2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi: 10.1074/jbc.M302945200 . PMID   12714592.
• Fukusumi S, Yoshida H, Fujii R, et al. (2004). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi: 10.1074/jbc.M305270200 . PMID   12960173.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Takayasu S, Sakurai T, Iwasaki S, et al. (2006). "A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7438–43. Bibcode:2006PNAS..103.7438T. doi: 10.1073/pnas.0602371103 . PMC   1464357 . PMID   16648250.

External links

• "Peptide P518 Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.