QRFP

QRFP
Identifiers
Aliases	QRFP , 26RFa, P518, pyroglutamylated RFamide peptide
External IDs	OMIM: 609795; MGI: 3630329; HomoloGene: 52341; GeneCards: QRFP; OMA:QRFP - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.12 Start 130,892,707 bp [1] End 130,896,812 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 B Start 31,696,178 bp [2] End 31,700,592 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad mucosa of transverse colon muscle layer of sigmoid colon stromal cell of endometrium popliteal artery tibial arteries sural nerve left coronary artery Descending thoracic aorta Top expressed in embryo islet of Langerhans white adipose tissue spermatocyte adrenal gland duodenum lip spleen hypothalamus uterus More reference expression data BioGPS n/a
Gene ontology Molecular function orexigenic neuropeptide QRFP receptor binding neuropeptide hormone activity Cellular component extracellular region cellular component Biological process grooming behavior positive regulation of blood pressure neuropeptide signaling pathway regulation of feeding behavior locomotory behavior regulation of signaling receptor activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 347148 227717 Ensembl ENSG00000188710 ENSMUSG00000043102 UniProt P83859 Q8CE23 RefSeq (mRNA) NM_198180 NM_183424 RefSeq (protein) NP_937823 NP_906269 Location (UCSC) Chr 9: 130.89 – 130.9 Mb Chr 2: 31.7 – 31.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein. ^[5]

The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. ^[6] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000188710 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043102 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide".
6. Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi: 10.1074/jbc.M302945200 . PMID   12714592.
7. Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi: 10.1074/jbc.M305270200 . PMID   12960173.

External links

• "Peptide P518 Receptor". IUPHAR/BPS Guide to PHARMACOLOGY.

Further reading

• Bruzzone F, Lectez B, Tollemer H, et al. (2007). "Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord". J. Neurochem. 99 (2): 616–27. doi:10.1111/j.1471-4159.2006.04090.x. PMID   16899066. S2CID   41427365.
• Chartrel N, Bruzzone F, Dujardin C, et al. (2006). "Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals". Ann. N. Y. Acad. Sci. 1040 (1): 80–3. Bibcode:2005NYASA1040...80C. doi:10.1196/annals.1327.009. PMID   15891009. S2CID   21012765.
• Thuau R, Guilhaudis L, Ségalas-Milazzo I, et al. (2005). "Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity". Peptides. 26 (5): 779–89. doi:10.1016/j.peptides.2005.01.006. PMID   15808908. S2CID   24088690.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Chartrel N, Dujardin C, Anouar Y, et al. (2004). "Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 15247–52. Bibcode:2003PNAS..10015247C. doi: 10.1073/pnas.2434676100 . PMC   299975 . PMID   14657341.
• Fukusumi S, Yoshida H, Fujii R, et al. (2004). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi: 10.1074/jbc.M305270200 . PMID   12960173.
• Jiang Y, Luo L, Gustafson EL, et al. (2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi: 10.1074/jbc.M302945200 . PMID   12714592.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.