Endothelin A receptor

Last updated
EDNRA
Identifiers
Aliases EDNRA , ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR, MFDA, endothelin receptor type A
External IDs OMIM: 131243 MGI: 105923 HomoloGene: 1478 GeneCards: EDNRA
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166055
NM_001256283
NM_001957
NM_001354797

NM_010332

RefSeq (protein)

NP_001159527
NP_001948
NP_001341726

NP_034462

Location (UCSC) Chr 4: 147.48 – 147.54 Mb Chr 8: 78.39 – 78.45 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor. [5]

Contents

Interactions

Endothelin receptor type A has been shown to interact with HDAC7A [6] and HTATIP. [6]

See also

Related Research Articles

<span class="mw-page-title-main">Thyrotropin-releasing hormone receptor</span> Protein-coding gene in the species Homo sapiens

Thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds thyrotropin-releasing hormone.

<span class="mw-page-title-main">GPVI</span> Protein-coding gene in the species Homo sapiens

Glycoprotein VI (platelet), also known as GPVI, is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GPVI gene. GPVI was first cloned in 2000 by several groups including that of Martine Jandrot-Perrus from INSERM.

Muscarinic acetylcholine receptor M<sub>5</sub> Protein-coding gene in the species Homo sapiens

The human muscarinic acetylcholine receptor M5, encoded by the CHRM5 gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins. It is coupled to Gq protein. Binding of the endogenous ligand acetylcholine to the M5 receptor triggers a number of cellular responses such as adenylate cyclase inhibition, phosphoinositide degradation, and potassium channel modulation. Muscarinic receptors mediate many of the effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor have not been fully explored; however, stimulation of this receptor is known to effectively decrease cyclic AMP levels and downregulate the activity of protein kinase A (PKA).

<span class="mw-page-title-main">Caveolin 1</span> Protein-coding gene in the species Homo sapiens

Caveolin-1 is a protein that in humans is encoded by the CAV1 gene.

<span class="mw-page-title-main">ITPR1</span> Protein-coding gene in the species Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.

<span class="mw-page-title-main">TRAF5</span> Protein-coding gene in the species Homo sapiens

TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.

<span class="mw-page-title-main">Alpha-2A adrenergic receptor</span> Protein-coding gene in the species Homo sapiens

The alpha-2A adrenergic receptor, also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the human gene encoding it.

<span class="mw-page-title-main">GNAI2</span> Protein-coding gene in humans

Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene.

<span class="mw-page-title-main">GNAI1</span> Protein-coding gene in humans

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.

<span class="mw-page-title-main">Testicular receptor 4</span> Protein-coding gene in the species Homo sapiens

Testicular receptor 4 also known as NR2C2 is a protein that in humans is encoded by the NR2C2 gene.

<span class="mw-page-title-main">Natriuretic peptide precursor C</span> Protein-coding gene in the species Homo sapiens

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene. The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).

<span class="mw-page-title-main">Endothelin receptor type B</span> Protein-coding gene in the species Homo sapiens

Endothelin receptor type B, (ET-B) is a protein that in humans is encoded by the EDNRB gene.

<span class="mw-page-title-main">P2RY6</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.

<span class="mw-page-title-main">Frizzled-6</span> Protein-coding gene in the species Homo sapiens

Frizzled-6(Fz-6) is a protein that in humans is encoded by the FZD6 gene.

<span class="mw-page-title-main">FUT7</span> Protein-coding gene in the species Homo sapiens

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene.

<span class="mw-page-title-main">NCKAP1</span> Protein-coding gene in the species Homo sapiens

Nck-associated protein 1 is a protein that in humans is encoded by the NCKAP1 gene.

<span class="mw-page-title-main">GRLF1</span> Protein-coding gene in the species Homo sapiens

Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.

<span class="mw-page-title-main">TRAK2</span> Protein-coding gene in the species Homo sapiens

Trafficking kinesin-binding protein 2 is a protein that in humans is encoded by the TRAK2 gene.

<span class="mw-page-title-main">PRKG1</span> Protein-coding gene in the species Homo sapiens

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.

<span class="mw-page-title-main">GNAI3</span> Protein-coding gene in humans

Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000151617 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031616 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: EDNRA endothelin receptor type A".
  6. 1 2 Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". The Journal of Biological Chemistry. 276 (20): 16597–600. doi: 10.1074/jbc.C000909200 . PMID   11262386.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.