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Names | |
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Preferred IUPAC name Methyl (3aR,4S,7aR)-4-hydroxy-4-[(3-methylphenyl)ethynyl]octahydro-1H-indole-1-carboxylate | |
Other names AFQ056 | |
Identifiers | |
3D model (JSmol) | |
ChemSpider | |
ECHA InfoCard | 100.219.728 |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C19H23NO3 | |
Molar mass | 313.397 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Mavoglurant (developmental code name AFQ-056) is an experimental drug candidate for the treatment of fragile X syndrome and other conditions. [1] [2] It exerts its effect as an antagonist of the metabotropic glutamate receptor 5 (mGluR5). [3] [4] [5]
Mavoglurant was under development by Novartis and reached phase II and phase III clinical trials. [2] [6] Phase IIb/III dose finding and evaluation trials for fragile X-syndrome were discontinued by the end of 2014. [7] Otherwise, it would have been the first drug to treat the underlying disorder instead of the symptoms of fragile X syndrome. [8] Mavoglurant was also in phase II clinical trials for Levodopa-induced dyskinesia. [9] [10] In 2007, Norvartis had conducted a clinical study to assess its ability of reducing cigarette smoking, but no results had been published up till now. [11] Novartis was conducting a clinical trial with this drug on obsessive–compulsive disorder. [12]
Novartis discontinued development of mavoglurant for fragile X syndrome in April 2014 following disappointing trial results. [7] Development was discontinued for other indications by 2017. [1]
Recently, Stalicla, a biotech company applying artificial intelligence to identify subgroups of high-responder patients, acquired worldwide rights from Novartis to progress the drug for substance-use and neurodevelopmental disorders. [13] [14] [15]