BAY 36-7620

Last updated
BAY 36-7620 [1]
BAY 36-7620.svg
Names
IUPAC name
(3aS,6aS)-5-methylidene-3a-(naphthalen-2-ylmethyl)-1,4,6,6a-tetrahydrocyclopenta[c]furan-3-one
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
UNII
  • InChI=1S/C19H18O2/c1-13-8-17-12-21-18(20)19(17,10-13)11-14-6-7-15-4-2-3-5-16(15)9-14/h2-7,9,17H,1,8,10-12H2/t17-,19+/m1/s1
    Key: CVIRWLJKDBYYOG-MJGOQNOKSA-N
  • C=C1C[C@@H]2COC(=O)[C@@]2(C1)CC3=CC4=CC=CC=C4C=C3
Properties
C19H18O2
Molar mass 278.351 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

BAY 36-7620 is an antagonist at mGluR1 receptors. [2] It has a IC50 value of 160 nM at the receptor. [3] This compound has been used to study metabotropic glutamate receptors, along with other chemicals. [4] [5]

Effects

When used on rats in vivo, BAY 36-7620 has anticonvulsant and neuroprotective effects, while lacking side effects present with ionotropic glutamate receptor antagonists. [6]

References

  1. ↑ PubChem. "Bay 367620". pubchem.ncbi.nlm.nih.gov. Retrieved 2025-08-02.
  2. ↑ Schröder, U. H.; Müller, T.; Schreiber, R.; Stolle, A.; Zuschratter, W.; Balschun, D.; Jork, R.; Reymann, K. G. (2008-11-19). "The potent non-competitive mGlu1 receptor antagonist BAY 36-7620 differentially affects synaptic plasticity in area cornu ammonis 1 of rat hippocampal slices and impairs acquisition in the water maze task in mice". Neuroscience. 157 (2): 385–395. doi:10.1016/j.neuroscience.2008.08.063. ISSN   0306-4522. PMID   18832015.
  3. ↑ "AID 313149 - Antagonist activity at mGlu1 receptor - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2025-08-02.
  4. ↑ Lavreysen, Hilde; Janssen, Cor; Bischoff, François; Langlois, Xavier; Leysen, Josée E.; Lesage, Anne S. J. (May 2003). "[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists". Molecular Pharmacology. 63 (5): 1082–1093. doi:10.1124/mol.63.5.1082. ISSN   0026-895X. PMID   12695537.
  5. ↑ Leembruggen, Anita J. L.; Lu, Yuqing; Wang, Haozhe; Uzungil, Volkan; Renoir, Thibault; Hannan, Anthony J.; Stamp, Lincon A.; Hao, Marlene M.; Bornstein, Joel C. (2023-01-09). "Group I Metabotropic Glutamate Receptors Modulate Motility and Enteric Neural Activity in the Mouse Colon". Biomolecules. 13 (1): 139. doi: 10.3390/biom13010139 . ISSN   2218-273X. PMC   9856182 . PMID   36671524.
  6. ↑ De Vry, J.; Horváth, E.; Schreiber, R. (2001-10-05). "Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620". European Journal of Pharmacology. 428 (2): 203–214. doi:10.1016/s0014-2999(01)01296-1. ISSN   0014-2999. PMID   11675037.
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