MMPIP

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MMPIP
MMPIP.png
Two-dimensional molecular structure
Identifiers
  • 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C19H15N3O3
Molar mass 333.347 g·mol−1
3D model (JSmol)
  • COc3ccc(cc3)C2CC(C1C(=O)N2C)ON=C1c4ccncc4
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MMPIP is a drug used in scientific research that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR7. [1] This receptor subtype appears to be involved in the downstream response to cocaine in the brain. [2]

References

  1. ↑ Suzuki G, Tsukamoto N, Fushiki H, Kawagishi A, Nakamura M, Kurihara H, Mitsuya M, Ohkubo M, Ohta H (October 2007). "In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists". The Journal of Pharmacology and Experimental Therapeutics. 323 (1): 147–56. doi:10.1124/jpet.107.124701. PMID   17609420. S2CID   10402176.
  2. ↑ Li X, Li J, Peng XQ, Spiller K, Gardner EL, Xi ZX (June 2009). "Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism". Neuropsychopharmacology. 34 (7): 1783–96. doi:10.1038/npp.2008.236. PMC   3739975 . PMID   19158667.


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