MTEP

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MTEP
Mtep.png
MTEP-3D-spacefill.png
Identifiers
  • 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
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Chemical and physical data
Formula C11H8N2S
Molar mass 200.26 g·mol−1
3D model (JSmol)
  • CC1=NC(=CS1)C#CC2=CN=CC=C2
  • InChI=1S/C11H8N2S/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10/h2-3,6-8H,1H3 X mark.svgN
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3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. Identified through structure-activity relationship studies on an older mGluR5 antagonist MPEP, [1] MTEP has subsequently itself acted as a lead compound for newer and even more improved drugs. [2] [3]

MTEP is both more potent and more selective than MPEP as a mGluR5 antagonist, [4] and produces similar neuroprotective, [5] [6] [7] antidepressant, [8] [9] [10] [11] analgesic, [12] [13] and anxiolytic effects but with either similar or higher efficacy depending on the test used. [14] [15] [16] [17]

MTEP also has similar efficacy to MPEP in reducing the symptoms of morphine withdrawal, [18] [19] [20] and has anti-addictive effects in a variety of animal models, both reducing ethanol self-administration, [21] [22] [23] [24] and also decreasing the addictive effects of nicotine, cocaine and methamphetamine. [25] [26] [27] [28] [29]

See also

Related Research Articles

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References

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