CXCL17

Last updated
chemokine (C-X-C motif) ligand 7
Identifiers
SymbolCXCL17
Alt. symbolsSCYB17, VCC-1, DMC
NCBI gene 284340
RefSeq NM_198477
UniProt Q6UXB2
Other data
Locus Chr. 19 q13.2
Search for
Structures Swiss-model
Domains InterPro

Chemokine (C-X-C motif) ligand 17 (CXCL17) is a small cytokine initially thought to belong to the CXC chemokine family, then addressed as chemokine-like protein, that has been identified in humans and mice.

Contents

CXCL17 has been previously reported to attract dendritic cells and monocytes, but there are also studies not reporting this activity [1] ; it is also regulated in tumors. It was formerly known as VEGF co-regulated chemokine 1 (VCC-1) and dendritic cell- and monocyte-attracting chemokine-like protein (DMC). [2] [3] This chemokine is constitutively expressed in the respiratory tract and more specifically in the lung. [3] The gene for human CXCL17 is located on chromosome 19. [3] Human and murine CXCL17 protein share 71% of amino acid sequence identity [4] .

Doubt has been expressed that CXCL17 should truly be considered a member of the chemokine ligand family and it has therefore been described as a "Black Sheep". [5]

Function

Being expressed in the respiratory tract mucosa, CXCL17 is likely to exert functions related to both immune surveillance of the tissue by fostering immune activation and immune suppression in case of overactivation of the immune system against harmless environmental antigens that can be commonly inhaled. CXCL17 also shows some anti-microbial activity against some bacteria, such as E.coli, S. aureus, Salmonella, P. aeruginosa and C. albicans strains.

Receptor

The receptor for CXCL17 is a G protein-coupled receptor (GPCR). The GPCR GPR35 was thought to be a receptor of CXCL17 [6] Subsequent research has suggested that GPR35 is not a receptor for CXCL17. [7] [8] . Indeed, recently GPR25 has been uniquely identified as CXCL17 receptor [9]


References

  1. ↑ Ocón, Borja; Xiang, Menglan; Bi, Yuhan; Tan, Serena; Brulois, Kevin; Ayesha, Aiman; Kunte, Manali; Zhou, Catherine; LaJevic, Melissa; Lazarus, Nicole; Mengoni, Francesca; Sharma, Tanya; Montgomery, Stephen; Hooper, Jody E.; Huang, Mian; Handel, Tracy; Dawson, John R. D.; Kufareva, Irina; Zabel, Brian A.; Pan, Junliang; Butcher, Eugene C. (21 November 2024). "A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS". Nature. 635 (8039): 736–745. Bibcode:2024Natur.635..736O. doi:10.1038/s41586-024-08043-2. PMC   11887596 . PMID   39293486.
  2. ↑ Weinstein EJ, Head R, Griggs DW, Sun D, Evans RJ, Swearingen ML, Westlin MM, Mazzarella R (November 2006). "VCC-1, a novel chemokine, promotes tumor growth". Biochemical and Biophysical Research Communications. 350 (1): 74–81. Bibcode:2006BBRC..350...74W. doi:10.1016/j.bbrc.2006.08.194. PMID   16989774.
  3. 1 2 3 Pisabarro MT, Leung B, Kwong M, Corpuz R, Frantz GD, Chiang N, Vandlen R, Diehl LJ, Skelton N, Kim HS, Eaton D, Schmidt KN (February 2006). "Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods". Journal of Immunology. 176 (4): 2069–73. doi: 10.4049/jimmunol.176.4.2069 . PMID   16455961.
  4. ↑ Choreño-Parra, José Alberto; Thirunavukkarasu, Shyamala; Zúñiga, Joaquín; Khader, Shabaana A. (June 2020). "The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine". Cytokine & Growth Factor Reviews. 53: 53–62. doi:10.1016/j.cytogfr.2020.04.004. PMC   7177079 . PMID   32345516.
  5. ↑ Denisov, SS (July 2021). "CXCL17: The Black Sheep in the Chemokine Flock". Frontiers in Immunology. 12 712897. doi: 10.3389/fimmu.2021.712897 . PMID   34335630.
  6. ↑ Maravillas-Montero JL, Burkhardt AM, Hevezi PA, Carnevale CD, Smit MJ, Zlotnik A (January 2015). "Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17". Journal of Immunology. 194 (1): 29–33. doi:10.4049/jimmunol.1401704. PMC   4355404 . PMID   25411203.
  7. ↑ Binti Mohd Amir NA, Mackenzie AE, Jenkins L, Boustani K, Hillier MC, Tsuchiya T, Milligan G, Pease JE (June 2018). "Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35". Journal of Immunology. 201 (2): 714–724. doi:10.4049/jimmunol.1700884. PMC   6036231 . PMID   29875152.
  8. ↑ Park SJ, Lee SJ, Nam SY, Im DS (January 2018). "GPR35 mediates lodoxamide-induced migration inhibitory response but not CXCL17-induced migration stimulatory response in THP-1 cells; is GPR35 a receptor for CXCL17?". British Journal of Pharmacology. 175 (1): 154–161. doi:10.1111/bph.14082. PMC   5740256 . PMID   29068046.
  9. ↑ Ocón, Borja; Xiang, Menglan; Bi, Yuhan; Tan, Serena; Brulois, Kevin; Ayesha, Aiman; Kunte, Manali; Zhou, Catherine; LaJevic, Melissa; Lazarus, Nicole; Mengoni, Francesca; Sharma, Tanya; Montgomery, Stephen; Hooper, Jody E.; Huang, Mian; Handel, Tracy; Dawson, John R. D.; Kufareva, Irina; Zabel, Brian A.; Pan, Junliang; Butcher, Eugene C. (21 November 2024). "A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS". Nature. 635 (8039): 736–745. Bibcode:2024Natur.635..736O. doi:10.1038/s41586-024-08043-2. PMC   11887596 . PMID   39293486.
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