IFNA6

IFNA6
Identifiers
Aliases	IFNA6 , IFN-alphaK, interferon alpha 6
External IDs	OMIM: 147566 HomoloGene: 105727 GeneCards: IFNA6
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p21.3 Start 21,349,835 bp [1] End 21,351,378 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in putamen caudate nucleus Brodmann area 9 amygdala substantia nigra hippocampus proper occipital lobe nucleus accumbens hypothalamus spinal cord n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space cellular component Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response cytokine-mediated signaling pathway innate immune response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3443 n/a Ensembl ENSG00000120235 n/a UniProt P05013 n/a RefSeq (mRNA) NM_021002 n/a RefSeq (protein) NP_066282 n/a Location (UCSC) Chr 9: 21.35 – 21.35 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Interferon alpha-6 is a protein that in humans is encoded by the IFNA6 gene. ^{[3] [4]}

References

1. GRCh38: Ensembl release 89: ENSG00000120235 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID   1385305.
4. "Entrez Gene: IFNA6 interferon, alpha 6".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Hardy MP, Owczarek CM, Jermiin LS, et al. (2005). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID   15233997.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329. ( Pt 2) (2): 295–302. doi:10.1042/bj3290295. PMC   1219044 . PMID   9425112.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC   231390 . PMID   8668211.
• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID   4057246.