IFNA16

IFNA16
Identifiers
Aliases	IFNA16 , IFN-alphaO, IFN-alpha-16, interferon, alpha 16, interferon alpha 16
External IDs	OMIM: 147580; MGI: 2667155; HomoloGene: 105364; GeneCards: IFNA16; OMA:IFNA16 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p21.3 Start 21,216,373 bp [1] End 21,217,311 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 C4|4 42.02 cM Start 88,561,878 bp [2] End 88,562,696 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cell monocyte Top expressed in embryo embryo More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response cytokine-mediated signaling pathway innate immune response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3449 230396 Ensembl ENSG00000147885 ENSMUSG00000063376 UniProt P05015 Q80SU4 RefSeq (mRNA) NM_002173 NM_177347 RefSeq (protein) NP_002164 NP_796321 Location (UCSC) Chr 9: 21.22 – 21.22 Mb Chr 4: 88.56 – 88.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interferon alpha-16, also known as IFN-alpha-16, is a protein that in humans is encoded by theIFNA16 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000147885 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: interferon".
6. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (October 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID   1385305.

Further reading

• Shirazi Y, Pitha PM (1993). "Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells". Virology. 193 (1): 303–12. doi: 10.1006/viro.1993.1126 . PMID   8438572.
• Chen YH, Böck G, Vornhagen R, Steindl F, Katinger H, Dierich MP (1994). "HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells". Int. Arch. Allergy Immunol. 104 (3): 227–31. doi:10.1159/000236670. PMID   7913356.
• Dianzani F, Castilletti C, Gentile M, Gelderblom HR, Frezza F, Capobianchi MR (1998). "Effects of IFN alpha on late stages of HIV-1 replication cycle". Biochimie. 80 (8–9): 745–54. doi:10.1016/S0300-9084(99)80028-5. PMID   9865497.
• Zagury JF, Chams V, Lachgar A, Achour A, Bizzini B, Burny A, Zagury D, Feldman M (1995). "Are CD4 and Fas peptide identities of gp120 relevant to the molecular basis of AIDS pathogenesis?". Cell Death Differ. 2 (1): 23–32. PMID   17180012.
• Myers MP, Andersen JN, Cheng A, Tremblay ML, Horvath CM, Parisien JP, Salmeen A, Barford D, Tonks NK (2001). "TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B". J. Biol. Chem. 276 (51): 47771–4. doi: 10.1074/jbc.C100583200 . PMID   11694501.
• Cicala C, Arthos J, Selig SM, Dennis Jr G, Hosack DA, Van Ryk D, Spangler ML, Steenbeke TD, Khazanie P (2002). "HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9380–5. Bibcode:2002PNAS...99.9380C. doi: 10.1073/pnas.142287999 . PMC   123149 . PMID   12089333.
• Schmidt B, Ashlock BM, Foster H, Fujimura SH, Levy JA (2005). "HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration". Virology. 343 (2): 256–66. doi:10.1016/j.virol.2005.09.059. PMID   16278001.
• Kinzl P, Otani T, Benz R, Minowada J (1997). "Interferon-alpha and -gamma differentially reduce rapid immature T-cell death by contact with HIV-1 carrier cell clones in vitro". Microbiol. Immunol. 41 (9): 709–16. doi: 10.1111/j.1348-0421.1997.tb01915.x . PMID   9343822. S2CID   85304106.
• Francis ML, Meltzer MS (1993). "Induction of IFN-alpha by HIV-1 in monocyte-enriched PBMC requires gp120-CD4 interaction but not virus replication". J. Immunol. 151 (4): 2208–16. doi:10.4049/jimmunol.151.4.2208. PMID   8345204.
• Peng G, Lei KJ, Jin W, Greenwell-Wild T, Wahl SM (2006). "Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity". J. Exp. Med. 203 (1): 41–6. doi:10.1084/jem.20051512. PMC   2118075 . PMID   16418394.
• Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7. doi:10.1038/ejhg.2010.98. PMC   2950898 . PMID   20588308.
• Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, Yeager M, Chanock S, Tucker MA (2010). "Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations". Fam. Cancer. 9 (4): 625–33. doi:10.1007/s10689-010-9356-3. PMC   3233727 . PMID   20574843.
• Popik W, Hesselgesser JE, Pitha PM (1998). "Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway". J. Virol. 72 (8): 6406–13. doi:10.1128/JVI.72.8.6406-6413.1998. PMC   109793 . PMID   9658081.
• Gessani S, Borghi P, Fantuzzi L, Varano B, Conti L, Puddu P, Belardelli F (1997). "Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation". J. Leukoc. Biol. 62 (1): 49–53. doi: 10.1002/jlb.62.1.49 . PMID   9225992. S2CID   31546644.
• Del Cornò M, Gauzzi MC, Penna G, Belardelli F, Adorini L, Gessani S (2005). "Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells". J. Virol. 79 (19): 12597–601. doi:10.1128/JVI.79.19.12597-12601.2005. PMC   1211530 . PMID   16160188.
• Sen GC, Lengyel P (1992). "The interferon system. A bird's eye view of its biochemistry". J. Biol. Chem. 267 (8): 5017–20. doi: 10.1016/S0021-9258(18)42719-6 . PMID   1371992.
• Taoufik Y, Lantz O, Wallon C, Charles A, Dussaix E, Delfraissy JF (1997). "Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect". Blood. 89 (8): 2842–8. doi: 10.1182/blood.V89.8.2842 . PMID   9108403.
• Conti L, Fantuzzi L, Del Cornò M, Belardelli F, Gessani S (2004). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology. 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID   15481145.
• Schols D, De Clercq E (1996). "Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production". J. Virol. 70 (8): 4953–60. doi:10.1128/JVI.70.8.4953-4960.1996. PMC   190447 . PMID   8764000.
• Ankel H, Capobianchi MR, Frezza F, Castilletti C, Dianzani F (1996). "Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids". Virology. 221 (1): 113–9. doi: 10.1006/viro.1996.0357 . PMID   8661419.