C-C motif chemokine ligand 27

CCL27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KUM
Identifiers
Aliases	CCL27 , ALP, CTACK, CTAK, ESKINE, ILC, PESKY, SCYA27, C-C motif chemokine ligand 27
External IDs	OMIM: 604833; MGI: 1891389; HomoloGene: 104838; GeneCards: CCL27; OMA:CCL27 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p13.3 Start 34,661,880 bp [1] End 34,664,048 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 A5|4 Start 42,655,251 bp [2] End 42,656,005 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg testicle gonad stromal cell of endometrium ganglionic eminence ventricular zone primary visual cortex left testis skeletal muscle tissue Top expressed in zone of skin pelvic ganglion lip placenta spermatocyte urethra female urethra adrenal gland male urethra thymus More reference expression data BioGPS n/a
Gene ontology Molecular function chemokine activity cytokine activity CCR3 chemokine receptor binding protein binding Cellular component extracellular region extracellular space Biological process chemotaxis cell-cell signaling immune response cell chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity G protein-coupled receptor signaling pathway positive regulation of T cell chemotaxis positive regulation of mononuclear cell migration positive regulation of actin cytoskeleton reorganization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10850 100040048 Ensembl ENSG00000213927 ENSMUSG00000096826 UniProt Q9Y4X3 Q9Z1X0 RefSeq (mRNA) NM_006664 NM_001199959 NM_001199960 NM_001199961 RefSeq (protein) NP_006655 NP_001041644 NP_001157516 NP_001157517 NP_001333994 NP_001348175 NP_035466 Location (UCSC) Chr 9: 34.66 – 34.66 Mb Chr 4: 42.66 – 42.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

chemokine (C-C motif) ligand 27
Identifiers
Symbol	CCL27
Alt. symbols	SCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
NCBI gene	10850
HGNC	10626
OMIM	604833
RefSeq	NM_006664
UniProt	Q9Y4X3
Other data
Locus	Chr. 9 q13
Search for Structures Swiss-model Domains InterPro

C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene. ^[5]

Function

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. CCL27 is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin. ^{[6] [7]} CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10. ^[8] The gene for CCL27 is located on human chromosome 9. ^[9] Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014].

References

1. GRCh38: Ensembl release 89: ENSG00000213927 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000096826 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: C-C motif chemokine ligand 27" . Retrieved 2018-03-23.
6. Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
7. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, et al. (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nature Medicine. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID   11821900. S2CID   35433583.
8. Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, et al. (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". Journal of Immunology. 164 (7): 3465–70. doi: 10.4049/jimmunol.164.7.3465 . PMID   10725697.
9. Ishikawa-Mochizuki I, Kitaura M, Baba M, Nakayama T, Izawa D, Imai T, et al. (November 1999). "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus". FEBS Letters. 460 (3): 544–8. Bibcode:1999FEBSL.460..544I. doi:10.1016/s0014-5793(99)01406-4. PMID   10556532. S2CID   39019419.

Further reading

• Mackay CR (February 2002). "New avenues for anti-inflammatory therapy". Nature Medicine. 8 (2): 117–8. doi:10.1038/nm0202-117. PMID   11821893. S2CID   26588760.
• Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, et al. (March 2003). "Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris". The Journal of Allergy and Clinical Immunology. 111 (3): 592–7. doi:10.1067/mai.2003.114. PMID   12642842.
• Hijnen D, De Bruin-Weller M, Oosting B, Lebre C, De Jong E, Bruijnzeel-Koomen C, Knol E (February 2004). "Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis". The Journal of Allergy and Clinical Immunology. 113 (2): 334–40. doi: 10.1016/j.jaci.2003.12.007 . PMID   14767451.
• Vestergaard C, Johansen C, Christensen U, Just H, Hohwy T, Deleuran M (September 2004). "TARC augments TNF-alpha-induced CTACK production in keratinocytes". Experimental Dermatology. 13 (9): 551–7. doi:10.1111/j.0906-6705.2004.00202.x. PMID   15335355. S2CID   84940084.
• Hirata T, Furukawa Y, Yang BG, Hieshima K, Fukuda M, Kannagi R, et al. (December 2004). "Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus". The Journal of Biological Chemistry. 279 (50): 51775–82. doi: 10.1074/jbc.M409868200 . PMID   15466853.
• Vestergaard C, Johansen C, Otkjaer K, Deleuran M, Iversen L (January 2005). "Tumor necrosis factor-alpha-induced CTACK/CCL27 (cutaneous T-cell-attracting chemokine) production in keratinocytes is controlled by nuclear factor kappaB". Cytokine. 29 (2): 49–55. doi:10.1016/j.cyto.2004.09.008. PMID   15598438.
• Spiekstra SW, Toebak MJ, Sampat-Sardjoepersad S, van Beek PJ, Boorsma DM, Stoof TJ, et al. (February 2005). "Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure". Experimental Dermatology. 14 (2): 109–16. doi:10.1111/j.0906-6705.2005.00226.x. PMID   15679580. S2CID   8770112.
• Kagami S, Saeki H, Komine M, Kakinuma T, Nakamura K, Tsunemi Y, et al. (February 2006). "CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27". Experimental Dermatology. 15 (2): 95–100. doi:10.1111/j.1600-0625.2005.00390.x. PMID   16433680. S2CID   31590665.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.