IL36A

IL36A
Identifiers
Aliases	IL36A , FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6, interleukin 36, alpha, interleukin 36 alpha
External IDs	OMIM: 605509; MGI: 1859324; HomoloGene: 8688; GeneCards: IL36A; OMA:IL36A - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q14.1 Start 113,005,459 bp [1] End 113,008,044 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 A3|2 16.26 cM Start 24,105,430 bp [2] End 24,115,714 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of esophagus testicle oral cavity mucosa of pharynx body of tongue pancreatic ductal cell buccal mucosa cell gums tonsil vagina Top expressed in esophagus lip cervix right ventricle skin of external ear umbilical cord tibiofemoral joint lumbar subsegment of spinal cord temporal muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-1 receptor binding cytokine activity Cellular component extracellular region extracellular space Biological process positive regulation of interleukin-6 production innate immune response positive regulation of cytokine production immune system process inflammatory response immune response regulation of signaling receptor activity cytokine-mediated signaling pathway neutrophil chemotaxis positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27179 54448 Ensembl ENSG00000136694 ENSMUSG00000026984 UniProt Q9UHA7 Q9JLA2 RefSeq (mRNA) NM_014440 NM_019450 RefSeq (protein) NP_055255 NP_062323 Location (UCSC) Chr 2: 113.01 – 113.01 Mb Chr 2: 24.11 – 24.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-36 alpha also known as interleukin-1 family member 6 (IL1F6) is a protein that in humans is encoded by the IL36A gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000136694 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026984 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (January 2000). "Four new members expand the interleukin-1 superfamily". The Journal of Biological Chemistry. 275 (2): 1169–1175. doi: 10.1074/jbc.275.2.1169 . PMID   10625660.
6. "Entrez Gene: IL1F6 interleukin 1 family, member 6 (epsilon)".

Further reading

• Nicklin MJ, Weith A, Duff GW (January 1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382–384. doi:10.1006/geno.1994.1076. PMID   8188271.
• Nothwang HG, Strahm B, Denich D, Kübler M, Schwabe J, Gingrich JC, Jauch A, Cox A, Nicklin MJ, Kurnit DM, Hildebrandt F (May 1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13". Genomics. 41 (3): 370–378. doi:10.1006/geno.1997.4654. PMID   9169134.
• Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (October 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochemical and Biophysical Research Communications. 263 (3): 702–706. doi:10.1006/bbrc.1999.1440. PMID   10512743.
• Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML, Young PR (April 2000). "Identification and initial characterization of four novel members of the interleukin-1 family". The Journal of Biological Chemistry. 275 (14): 10308–10314. doi: 10.1074/jbc.275.14.10308 . PMID   10744718.
• Busfield SJ, Comrack CA, Yu G, Chickering TW, Smutko JS, Zhou H, Leiby KR, Holmgren LM, Gearing DP, Pan Y (June 2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics. 66 (2): 213–216. doi:10.1006/geno.2000.6184. PMID   10860666.
• Barton JL, Herbst R, Bosisio D, Higgins L, Nicklin MJ (November 2000). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities". European Journal of Immunology. 30 (11): 3299–3308. doi: 10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S . PMID   11093146.
• Pan G, Risser P, Mao W, Baldwin DT, Zhong AW, Filvaroff E, Yansura D, Lewis L, Eigenbrot C, Henzel WJ, Vandlen R (January 2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine. 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID   11145836.
• Lin H, Ho AS, Haley-Vicente D, Zhang J, Bernal-Fussell J, Pace AM, Hansen D, Schweighofer K, Mize NK, Ford JE (June 2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". The Journal of Biological Chemistry. 276 (23): 20597–20602. doi: 10.1074/jbc.M010095200 . PMID   11278614.
• Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA (August 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology. 167 (3): 1440–1446. doi:10.4049/jimmunol.167.3.1440. PMID   11466363. S2CID   85986577.
• Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, Pan J, Pan Y, Smith DE, Young PR (October 2001). "A new nomenclature for IL-1-family genes". Trends in Immunology. 22 (10): 536–537. doi:10.1016/S1471-4906(01)02040-3. PMID   11574262.
• Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718–725. doi:10.1006/geno.2002.6751. PMID   11991722.
• Garnero P, Borel O, Sornay-Rendu E, Duboeuf F, Jeffery R, Woo P, Delmas PD (July 2002). "Association between a functional interleukin-6 gene polymorphism and peak bone mineral density and postmenopausal bone loss in women: the OFELY study". Bone. 31 (1): 43–50. doi:10.1016/S8756-3282(02)00810-4. PMID   12110411.
• Towne JE, Garka KE, Renshaw BR, Virca GD, Sims JE (April 2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs". The Journal of Biological Chemistry. 279 (14): 13677–13688. doi: 10.1074/jbc.M400117200 . PMID   14734551.
• Zhan X, Desiderio DM (July 2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Analytical Biochemistry. 354 (2): 279–289. doi:10.1016/j.ab.2006.05.024. PMID   16777052.
• Blumberg H, Dinh H, Trueblood ES, Pretorius J, Kugler D, Weng N, Kanaly ST, Towne JE, Willis CR, Kuechle MK, Sims JE, Peschon JJ (October 2007). "Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation". The Journal of Experimental Medicine. 204 (11): 2603–2614. doi:10.1084/jem.20070157. PMC   2118475 . PMID   17908936.