Interleukin 20 receptor, alpha subunit

IL20RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DOH
Identifiers
Aliases	IL20RA , CRF2-8, IL-20R-alpha, IL-20R1, IL-20RA, Interleukin 20 receptor, alpha subunit, interleukin 20 receptor subunit alpha
External IDs	OMIM: 605620 MGI: 3605069 HomoloGene: 8685 GeneCards: IL20RA
Gene location (Human)
Chr.	Chromosome 6 (human)
End	137,045,180 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	19,635,801 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; right uterine tube; ; bronchial epithelial cell; ; endometrium; ; palpebral conjunctiva; ; minor salivary gland; ; body of pancreas; ; vagina; ; islet of Langerhans; ; parotid gland;
	Top expressed in
	spermatid; ; lip; ; superior frontal gyrus; ; skin of abdomen; ; adrenal gland; ; skin of back; ; carotid body; ; esophagus; ; olfactory bulb; ; epidermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity ; interleukin-20 binding ; protein binding ;
Cellular component	integral component of membrane ; membrane ; plasma membrane ;
Biological process	regulation of bone resorption ; positive regulation of intrinsic apoptotic signaling pathway ; cytokine-mediated signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	53832
	237313
	ENSG00000016402
	ENSMUSG00000020007
	Q9UHF4
	Q6PHB0
	NM_001278722 ; NM_001278723 ; NM_001278724 ; NM_014432
	NM_172786
	NP_001265651 ; NP_001265652 ; NP_001265653 ; NP_055247
	NP_766374
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 14, 2023

Interleukin 20 receptor, alpha subunit, is a subunit of the interleukin-20 receptor, the interleukin-26 receptor, and the interleukin-24 receptor.^[5] The interleukin 20 receptor, alpha subunit is also referred to as IL20R1^[6] or IL20RA.^[7] The IL20RA receptor is involved in both pro-inflammatory and anti-inflammatory responses, signaling through the JAK-STAT pathway.^[5]

IL20RA is found in the skin, lungs, ovaries, testes and placenta, with low gene expression in the intestine and liver.^[7] IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RA is also found in some immune cells.^[8]

Structure and function

IL20RA is an alpha-chain with a long intracellular domain. IL20RA, along with the IL-20 receptor, beta subunit, form the heterodimeric interleukin-20 receptor, which binds the cytokines IL-19, IL-20 and IL-24. IL20RA also forms a complex with the IL-10 receptor, beta subunit, which binds the cytokine IL-26.^[5]

Signaling

Receptors made up of IL20RA signal through a JAK-STAT signaling pathway.^[5] In this pathway, after a cytokine binds IL20RA and the beta subunit, JAKs linked to intracellular domains of IL20R activate and phosphorylate tyrosine residues found in the longer alpha chains of IL20RA. STAT then binds to docking sites created by JAK phosphorylation and becomes phosphorylated by JAK. STATs then dimerize and move to the nucleus to act as transcription factors. The specific genes expressed are dependent on the specific JAK, STAT, as well as by SOCS proteins, which can inhibit the JAK-STAT signal, regulating it.where the transcription factor STAT3 binds to IL20RA and STAT3 becomes activated.^[1] IL20RA has multiple docking sites for STAT3.^[5]^[9]

Link to Immune System and Disease

Research indicates that IL20RA is found in some immune cells. For example, IL20RA is sometimes found in lung macrophages. Research indicates that IL20RA presence may be related to disease. In people with rheumatoid arthiritis, IL20RA is present in blood monocytes.^[8]

IL20RA has also been linked with psoriasis, and atherosclerosis, all diseases associated with inflammation. The specific role of IL20RA in these diseases is unknown.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000016402 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020007 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 5 Wegenka, Ursula Maria (2010-10-01). "IL-20: Biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. IL-10 Family of Cytokines. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. ISSN 1359-6101.
↑ Wirtz, Mary K.; Keller, Kate E. (2016). "The Role of the IL-20 Subfamily in Glaucoma". Mediators of Inflammation. 2016: 1–8. doi:10.1155/2016/4083735. ISSN 0962-9351. PMC 4745377 .
1 2 3 Rutz, Sascha; Wang, Xiaoting; Ouyang, Wenjun (December 2014). "The IL-20 subfamily of cytokines — from host defence to tissue homeostasis". Nature Reviews Immunology. 14 (12): 783–795. doi:10.1038/nri3766. ISSN 1474-1741.
1 2 Kragstrup, Tue W.; Andersen, Thomas; Heftdal, Line D.; Hvid, Malene; Gerwien, Jens; Sivakumar, Pallavur; Taylor, Peter C.; Senolt, Ladislav; Deleuran, Bent (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9. doi:10.3389/fimmu.2018.02226. ISSN 1664-3224. PMC 6167463 .
↑ Blumberg, Hal; Conklin, Darrell; Xu, WenFeng; Grossmann, Angelika; Brender, Ty; Carollo, Susan; Eagan, Maribeth; Foster, Don; Haldeman, Betty A; Hammond, Angie; Haugen, Harald; Jelinek, Laura; Kelly, James D; Madden, Karen; Maurer, Mark F (2001-01-12). "Interleukin 20: Discovery, Receptor Identification, and Role in Epidermal Function". Cell. 104 (1): 9–19. doi: 10.1016/S0092-8674(01)00187-8 . ISSN 0092-8674.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
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Dumoutier L, Leemans C, Lejeune D, et al. (2001). "Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types". J. Immunol. 167 (7): 3545–9. doi: 10.4049/jimmunol.167.7.3545 . PMID 11564763.
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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000016402 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020007 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:03-5] 1 2 3 4 5 Wegenka, Ursula Maria (2010-10-01). "IL-20: Biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. IL-10 Family of Cytokines. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. ISSN 1359-6101.

[6] Wirtz, Mary K.; Keller, Kate E. (2016). "The Role of the IL-20 Subfamily in Glaucoma". Mediators of Inflammation. 2016: 1–8. doi:10.1155/2016/4083735. ISSN 0962-9351. PMC 4745377 .

[:1-7] 1 2 3 Rutz, Sascha; Wang, Xiaoting; Ouyang, Wenjun (December 2014). "The IL-20 subfamily of cytokines — from host defence to tissue homeostasis". Nature Reviews Immunology. 14 (12): 783–795. doi:10.1038/nri3766. ISSN 1474-1741.

[:22-8] 1 2 Kragstrup, Tue W.; Andersen, Thomas; Heftdal, Line D.; Hvid, Malene; Gerwien, Jens; Sivakumar, Pallavur; Taylor, Peter C.; Senolt, Ladislav; Deleuran, Bent (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9. doi:10.3389/fimmu.2018.02226. ISSN 1664-3224. PMC 6167463 .

[9] Blumberg, Hal; Conklin, Darrell; Xu, WenFeng; Grossmann, Angelika; Brender, Ty; Carollo, Susan; Eagan, Maribeth; Foster, Don; Haldeman, Betty A; Hammond, Angie; Haugen, Harald; Jelinek, Laura; Kelly, James D; Madden, Karen; Maurer, Mark F (2001-01-12). "Interleukin 20: Discovery, Receptor Identification, and Role in Epidermal Function". Cell. 104 (1): 9–19. doi: 10.1016/S0092-8674(01)00187-8 . ISSN 0092-8674.

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