LILRB2

Last updated

LILRB2
Identifiers
Aliases LILRB2 , ILT4, MIR10, LIR2, MIR-10, LIR-2, leukocyte immunoglobulin like receptor B2, ILT-4, CD85D
External IDs OMIM: 604815 HomoloGene: 136797 GeneCards: LILRB2
Orthologs
SpeciesHumanMouse
Entrez

10288

n/a

Ensembl

n/a

UniProt

A2IXV5

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC) Chr 19: 54.27 – 54.28 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene. [3] [4] [5]

Contents

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [5]

LILBR2 plays a critical role in the inhibition of axonal regeneration and functional recovery after brain injury. [6] However, recent studies demonstrate that LILRB2 is a β-Amyloid receptor and may contribute to synaptic loss and cognitive impairment in Alzheimer's disease. [7] [8]

Interactions

LILRB2 has been shown to interact with PTPN6. [9] [10]

See also

Related Research Articles

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<span class="mw-page-title-main">LILRA3</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">LILRA2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">LILRA5</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily A member 5 (LILR-A5) also known as CD85 antigen-like family member F (CD85f), immunoglobulin-like transcript 11 (ILT-11), and leukocyte immunoglobulin-like receptor 9 (LIR-9) is a protein that in humans is encoded by the LILRA5 gene. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described.

References

  1. 1 2 3 ENSG00000275463, ENSG00000131042, ENSG00000276146, ENSG00000277751 GRCh38: Ensembl release 89: ENSG00000274513, ENSG00000275463, ENSG00000131042, ENSG00000276146, ENSG00000277751 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, et al. (May 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743–1751. doi:10.1084/jem.185.10.1743. PMC   2196312 . PMID   9151699.
  4. ↑ Samaridis J, Colonna M (March 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology. 27 (3): 660–665. doi: 10.1002/eji.1830270313 . PMID   9079806. S2CID   2212182.
  5. 1 2 "Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2".
  6. ↑ Mi YJ, Chen H, Guo N, Sun MY, Zhao ZH, Gao XC, et al. (2017). "Inhibition of PirB Activity by TAT-PEP Improves Mouse Motor Ability and Cognitive Behavior". Frontiers in Aging Neuroscience. 9: 199. doi: 10.3389/fnagi.2017.00199 . PMC   5476690 . PMID   28676756.
  7. ↑ Lao K, Zhang R, Dai Y, Luan J, Guo N, Xu X, et al. (July 2021). "Identification of novel Aβ-LilrB2 inhibitors as potential therapeutic agents for Alzheimer's disease". Molecular and Cellular Neurosciences. 114: 103630. doi:10.1016/j.mcn.2021.103630. PMID   34029694. S2CID   235203153.
  8. ↑ Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, et al. (September 2013). "Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model". Science. 341 (6152): 1399–1404. Bibcode:2013Sci...341.1399K. doi:10.1126/science.1242077. PMC   3853120 . PMID   24052308.
  9. ↑ Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (November 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". European Journal of Immunology. 28 (11): 3423–3434. doi: 10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2 . PMID   9842885.
  10. ↑ Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, et al. (April 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". Journal of Immunology. 160 (7): 3096–3100. doi: 10.4049/jimmunol.160.7.3096 . PMID   9531263. S2CID   255370078.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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