FCGR1A

Last updated
FCGR1A
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FCGR1A , CD64, CD64A, FCRI, IGFR1, Fc fragment of IgG receptor Ia
External IDs OMIM: 146760 MGI: 95498 HomoloGene: 475 GeneCards: FCGR1A
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000566

NM_010186

RefSeq (protein)

NP_034316

Location (UCSC) Chr 1: 149.78 – 149.79 Mb Chr 3: 96.19 – 96.2 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene. [5] [6] [7]

Interactions

The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif. [8]

Related Research Articles

<span class="mw-page-title-main">CD32</span> Surface receptor glycoprotein

CD32, also known as FcγRII or FCGR2, is a surface receptor glycoprotein belonging to the Ig gene superfamily. CD32 can be found on the surface of a variety of immune cells. CD32 has a low-affinity for the Fc region of IgG antibodies in monomeric form, but high affinity for IgG immune complexes. CD32 has two major functions: cellular response regulation, and the uptake of immune complexes. Cellular responses regulated by CD32 include phagocytosis, cytokine stimulation, and endocytic transport. Dysregulated CD32 is associated with different forms of autoimmunity, including systemic lupus erythematosus. In humans, there are three major CD32 subtypes: CD32A, CD32B, and CD32C. While CD32A and CD32C are involved in activating cellular responses, CD32B is inhibitory.

<span class="mw-page-title-main">CD23</span> Low-affinity" receptor for IgE

CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.

<span class="mw-page-title-main">Fc receptor</span> Surface protein important to the immune system

In immunology, an Fc receptor is a protein found on the surface of certain cells – including, among others, B lymphocytes, follicular dendritic cells, natural killer cells, macrophages, neutrophils, eosinophils, basophils, human platelets, and mast cells – that contribute to the protective functions of the immune system. Its name is derived from its binding specificity for a part of an antibody known as the Fc region. Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. Their activity stimulates phagocytic or cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity. Some viruses such as flaviviruses use Fc receptors to help them infect cells, by a mechanism known as antibody-dependent enhancement of infection.

<span class="mw-page-title-main">FCER1</span>

The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in allergy disorders and parasite immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE. It consists of one alpha, one beta, and two gamma chains connected by two disulfide bridges on mast cells and basophils. It lacks the beta subunit on other cells. It is constitutively expressed on mast cells and basophils and is inducible in eosinophils.

CD64 is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity. It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain, which possesses an ITAM motif that is necessary for triggering cellular activation.

CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages, and certain T cells. CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. The most well-researched membrane receptor implicated in triggering lysis by NK cells, CD16 is a molecule of the immunoglobulin superfamily (IgSF) involved in antibody-dependent cellular cytotoxicity (ADCC). It can be used to isolate populations of specific immune cells through fluorescent-activated cell sorting (FACS) or magnetic-activated cell sorting, using antibodies directed towards CD16.

<span class="mw-page-title-main">FCER1A</span> Protein-coding gene in the species Homo sapiens

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene.

<span class="mw-page-title-main">LILRB1</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.

<span class="mw-page-title-main">FCGR2A</span> Mammalian protein found in Homo sapiens

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.

<span class="mw-page-title-main">LAIR1</span> Protein-coding gene in the species Homo sapiens

Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene. LAIR1 has also been designated as CD305.

<span class="mw-page-title-main">LILRB2</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.

<span class="mw-page-title-main">LILRB4</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene.

<span class="mw-page-title-main">FCGR3A</span>

Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene. It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules.

<span class="mw-page-title-main">FCGR2B</span>

Fc fragment of IgG receptor IIb is a low affinity inhibitory receptor for the Fc region of immunoglobulin gamma (IgG). FCGR2B participates in the phagocytosis of immune complexes and in the regulation of antibody production by B lymphocytes.

<span class="mw-page-title-main">CD300LF</span> Protein-coding gene in the species Homo sapiens

CMRF35-like molecule 1, also known as CD300lf, is a protein that in humans is encoded by the CD300LF gene. CD300lf belongs to the protein family of CD300. CD300lf is a membrane glycoprotein that contains an immunoglobulin domain and is expressed by myeloid and mast cells of humans and other mammals. The protein functions in immunoregulation but might also have a role in norovirus infections.

<span class="mw-page-title-main">FCAR</span> Mammalian protein found in Homo sapiens

Fc fragment of IgA receptor (FCAR) is a human gene that codes for the transmembrane receptor FcαRI, also known as CD89. FcαRI binds the heavy-chain constant region of Immunoglobulin A (IgA) antibodies. FcαRI is present on the cell surface of myeloid lineage cells, including neutrophils, monocytes, macrophages, and eosinophils, though it is notably absent from intestinal macrophages and does not appear on mast cells. FcαRI plays a role in both pro- and anti-inflammatory responses depending on the state of IgA bound. Inside-out signaling primes FcαRI in order for it to bind its ligand, while outside-in signaling caused by ligand binding depends on FcαRI association with the Fc receptor gamma chain.

<span class="mw-page-title-main">FCGR3B</span>

FCGR3B, also known as CD16b, is a human gene.

<span class="mw-page-title-main">MS4A2</span> Protein-coding gene in the species Homo sapiens

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.

<span class="mw-page-title-main">LILRA1</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor, subfamily A, member 1 is a protein that in humans is encoded by the LILRA1 gene.

<span class="mw-page-title-main">FCER1G</span> Protein-coding gene in the species Homo sapiens

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide is a protein that in humans is encoded by the FCER1G gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000150337 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015947 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (September 1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21". Cytogenetics and Cell Genetics. 73 (3): 157–63. doi:10.1159/000134330. PMID   8697799.
  6. Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (November 1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1". Cytogenetics and Cell Genetics. 82 (1–2): 71–4. doi:10.1159/000015067. PMID   9763663. S2CID   20290009.
  7. "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)".
  8. The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N. Lambrecht FEBRUARY 2014 | VOLUME 14 Nature Reviews Immunology

Further reading