SIRPB1

SIRPB1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2D9C, 2JJU,%%s2JJV
Identifiers
Aliases	SIRPB1 , CD172b, SIRP-BETA-1, signal regulatory protein beta 1
External IDs	OMIM: 603889 MGI: 3779828 HomoloGene: 82993 GeneCards: SIRPB1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	1,620,061 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	15,640,125 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; right lung; ; spleen; ; bone marrow; ; bone marrow cells; ; appendix; ; gallbladder; ; lymph node; ; upper lobe of left lung;
	Top expressed in
	spermatid; ; secondary oocyte; ; bone marrow; ; spleen; ; lung; ; jejunum; ; liver; ; uterus; ; spermatocyte; ; ovary;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; membrane ; secretory granule membrane ; cell surface ;
Biological process	cell surface receptor signaling pathway ; innate immune response ; signal transduction ; neutrophil degranulation ; positive regulation of cell-cell adhesion ; positive regulation of phagocytosis ; positive regulation of T cell activation ;
	Sources:Amigo / QuickGO
Orthologs
	10326
	668101
	ENSG00000101307
	ENSMUSG00000095028
	O00241 ; Q5TFQ8
	n/a
	NM_001083910 ; NM_001135844 ; NM_006065 ; NM_001329157 ; NM_001330639 Contents Interactions ; References ; Further reading ; External links ;
	NM_001173460
NP_001077379 ; NP_001129316 ; NP_001316086 ; NP_001317568 ; NP_006056 ;
	NP_001129316.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 16, 2023

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.^[5]^[6]^[7] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.^[7]

Interactions

SIRPB1 has been shown to interact with TYROBP.^[8]^[9]

Related Research Articles

Chemokine ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.

Chemokine ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene.

Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.

Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. CCR6 has also recently been designated CD196. The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids.

TYRO protein tyrosine kinase-binding protein is an adapter protein that in humans is encoded by the TYROBP gene.

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.

Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.

CD244 also known as 2B4 or SLAMF4 is a protein that in humans is encoded by the CD244 gene.

Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor and the interleukin 23 receptor. IL12RB1, is the name of its human gene. IL-12Rβ1 is also known as CD212.

Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-induced apoptosis.

Killer cell immunoglobulin-like receptor 3DL2 is a protein that in humans is encoded by the KIR3DL2 gene.

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.

Interleukin 17 receptor A, also known as IL17RA and CDw217, is a human gene.

Killer cell immunoglobulin-like receptor 2DS4 is a protein that in humans is encoded by the KIR2DS4 gene.

Natural cytotoxicity triggering receptor 2 is a protein that in humans is encoded by the NCR2 gene. NCR2 has also been designated as CD336, NKp44, NKP44; NK-p44, LY95, and dJ149M18.1.

Hematopoietic cell signal transducer is a protein that in humans is encoded by the HCST gene.

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene. SIRPG has also recently been designated CD172G.

CD79b molecule, immunoglobulin-associated beta, also known as CD79B, is a human gene.

5-azacytidine-induced protein 2 is a protein that in humans is encoded by the AZI2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101307 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000095028 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kharitonenkov A; Chen Z; Sures I; Wang H; Schilling J; Ullrich A (April 1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181–6. Bibcode:1997Natur.386..181K. doi:10.1038/386181a0. PMID 9062191. S2CID 4259314.
↑ van den Berg TK; van Beek EM; Buhring HJ; Colonna M; Hamaguchi M; Howard CJ; Kasuga M; Liu Y; Matozaki T; Neel BG; Parkos CA; Sano S; Vignery A; Vivier E; Wright M; Zawatzky R; Barclay AN (December 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511.
1 2 "Entrez Gene: SIRPB1 signal-regulatory protein beta 1".
↑ Dietrich, J; Cella M; Seiffert M; Bühring H J; Colonna M (January 2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. UNITED STATES. 164 (1): 9–12. doi: 10.4049/jimmunol.164.1.9 . ISSN 0022-1767. PMID 10604985.
↑ Tomasello, E; Cant C; Bühring H J; Vély F; André P; Seiffert M; Ullrich A; Vivier E (August 2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. GERMANY. 30 (8): 2147–56. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. ISSN 0014-2980. PMID 10940905.

External links

SIRPB1 human gene location in the UCSC Genome Browser .
SIRPB1 human gene details in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101307 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000095028 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9062191-5] Kharitonenkov A; Chen Z; Sures I; Wang H; Schilling J; Ullrich A (April 1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181–6. Bibcode:1997Natur.386..181K. doi:10.1038/386181a0. PMID 9062191. S2CID 4259314.

[pmid16339511-6] van den Berg TK; van Beek EM; Buhring HJ; Colonna M; Hamaguchi M; Howard CJ; Kasuga M; Liu Y; Matozaki T; Neel BG; Parkos CA; Sano S; Vignery A; Vivier E; Wright M; Zawatzky R; Barclay AN (December 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511.

[entrez-7] 1 2 "Entrez Gene: SIRPB1 signal-regulatory protein beta 1".

[pmid10604985-8] Dietrich, J; Cella M; Seiffert M; Bühring H J; Colonna M (January 2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. UNITED STATES. 164 (1): 9–12. doi: 10.4049/jimmunol.164.1.9 . ISSN 0022-1767. PMID 10604985.

[pmid10940905-9] Tomasello, E; Cant C; Bühring H J; Vély F; André P; Seiffert M; Ullrich A; Vivier E (August 2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. GERMANY. 30 (8): 2147–56. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. ISSN 0014-2980. PMID 10940905.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

SIRPB1

Contents

Interactions

Related Research Articles

References

Further reading

External links