Interleukin 10 receptor, alpha subunit

IL10RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J7V, 1LQS, 1Y6K, 1Y6M, 1Y6N, 5IXI
Identifiers
Aliases	IL10RA , CD210, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R, Interleukin 10 receptor, alpha subunit, interleukin 10 receptor subunit alpha
External IDs	OMIM: 146933; MGI: 96538; HomoloGene: 1196; GeneCards: IL10RA; OMA:IL10RA - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q23.3 Start 117,986,370 bp [1] End 118,003,037 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 A5.2|9 24.84 cM Start 45,165,135 bp [2] End 45,180,447 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mononuclear cell monocyte blood spleen bone marrow cells lymph node appendix gallbladder rectum Top expressed in granulocyte spleen stroma of bone marrow mesenteric lymph nodes blood embryo ankle joint thymus subcutaneous adipose tissue superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding interleukin-10 binding signal transducer activity interleukin-10 receptor activity signaling receptor activity cytokine receptor activity Cellular component integral component of membrane membrane plasma membrane cytoplasm Biological process response to lipopolysaccharide regulation of synapse organization cytokine-mediated signaling pathway negative regulation of autophagy positive regulation of receptor signaling pathway via JAK-STAT ubiquitin-dependent endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3587 16154 Ensembl ENSG00000110324 ENSMUSG00000032089 UniProt Q13651 Q61727 RefSeq (mRNA) NM_001558 NM_008348 NM_001324486 RefSeq (protein) NP_001549 NP_001311415 NP_032374 Location (UCSC) Chr 11: 117.99 – 118 Mb Chr 9: 45.17 – 45.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its human gene.

IL10RA has also been designated CDw210a (cluster of differentiation w210a).

Function

See also: PI 3-kinase/AKT pathway

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of myeloid progenitor cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. ^[5]

Interactions

Interleukin 10 receptor, alpha subunit has been shown to interact with:

• Interleukin 10 ^{[6] [7] [8] [9] [10]} and
• Janus kinase 1. ^{[11] [12]}

References

1. GRCh38: Ensembl release 89: ENSG00000110324 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032089 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IL10RA interleukin 10 receptor, alpha".
6. Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (December 1993). "A receptor for interleukin 10 is related to interferon receptors". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11267–71. Bibcode:1993PNAS...9011267H. doi: 10.1073/pnas.90.23.11267 . PMC   47963 . PMID   8248239.
7. Josephson K, Logsdon NJ, Walter MR (July 2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity. 15 (1): 35–46. doi: 10.1016/s1074-7613(01)00169-8 . PMID   11485736.
8. Tan JC, Braun S, Rong H, DiGiacomo R, Dolphin E, Baldwin S, Narula SK, Zavodny PJ, Chou CC (May 1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor". J. Biol. Chem. 270 (21): 12906–11. doi: 10.1074/jbc.270.21.12906 . PMID   7759550.
9. Josephson K, McPherson DT, Walter MR (December 2001). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D. 57 (Pt 12): 1908–11. doi:10.1107/s0907444901016249. PMID   11717514.
10. Hoover DM, Schalk-Hihi C, Chou CC, Menon S, Wlodawer A, Zdanov A (May 1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization". Eur. J. Biochem. 262 (1): 134–41. doi: 10.1046/j.1432-1327.1999.00363.x . PMID   10231374.
11. Usacheva A, Sandoval R, Domanski P, Kotenko SV, Nelms K, Goldsmith MA, Colamonici OR (December 2002). "Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation". J. Biol. Chem. 277 (50): 48220–6. doi: 10.1074/jbc.M205757200 . PMID   12374810.
12. Usacheva A, Kotenko S, Witte MM, Colamonici OR (August 2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. 169 (3): 1302–8. doi: 10.4049/jimmunol.169.3.1302 . PMID   12133952.

Further reading

• Donnelly RP, Dickensheets H, Finbloom DS (1999). "The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes". J. Interferon Cytokine Res. 19 (6): 563–73. doi:10.1089/107999099313695. PMID   10433356. S2CID   35958614.
• Carson WE, Lindemann MJ, Baiocchi R, Linett M, Tan JC, Chou CC, Narula S, Caligiuri MA (1995). "The functional characterization of interleukin-10 receptor expression on human natural killer cells". Blood. 85 (12): 3577–85. doi: 10.1182/blood.V85.12.3577.bloodjournal85123577 . PMID   7540068.
• Ho AS, Wei SH, Mui AL, Miyajima A, Moore KW (1995). "Functional regions of the mouse interleukin-10 receptor cytoplasmic domain". Mol. Cell. Biol. 15 (9): 5043–53. doi:10.1128/mcb.15.9.5043. PMC   230751 . PMID   7544437.
• Tan JC, Braun S, Rong H, DiGiacomo R, Dolphin E, Baldwin S, Narula SK, Zavodny PJ, Chou CC (1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor". J. Biol. Chem. 270 (21): 12906–11. doi: 10.1074/jbc.270.21.12906 . PMID   7759550.
• Taniyama T, Takai S, Miyazaki E, Fukumura R, Sato J, Kobayashi Y, Hirakawa T, Moore KW, Yamada K (1995). "The human interleukin-10 receptor gene maps to chromosome 11q23.3". Hum. Genet. 95 (1): 99–101. doi:10.1007/BF00225083. PMID   7814035. S2CID   205672.
• Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW (1994). "Expression cloning and characterization of a human IL-10 receptor". J. Immunol. 152 (4): 1821–9. doi: 10.4049/jimmunol.152.4.1821 . PMID   8120391.
• Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (1994). "A receptor for interleukin 10 is related to interferon receptors". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11267–71. Bibcode:1993PNAS...9011267H. doi: 10.1073/pnas.90.23.11267 . PMC   47963 . PMID   8248239.
• Tan JC, Indelicato SR, Narula SK, Zavodny PJ, Chou CC (1993). "Characterization of interleukin-10 receptors on human and mouse cells". J. Biol. Chem. 268 (28): 21053–9. doi: 10.1016/S0021-9258(19)36892-9 . PMID   8407942.
• Lai CF, Ripperger J, Morella KK, Jurlander J, Hawley TS, Carson WE, Kordula T, Caligiuri MA, Hawley RG, Fey GH, Baumann H (1996). "Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements". J. Biol. Chem. 271 (24): 13968–75. doi: 10.1074/jbc.271.24.13968 . PMID   8662928.
• Zdanov A, Schalk-Hihi C, Wlodawer A (1997). "Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor". Protein Sci. 5 (10): 1955–62. doi:10.1002/pro.5560051001. PMC   2143256 . PMID   8897595.
• Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex". EMBO J. 16 (19): 5894–903. doi:10.1093/emboj/16.19.5894. PMC   1170220 . PMID   9312047.
• Hoover DM, Schalk-Hihi C, Chou CC, Menon S, Wlodawer A, Zdanov A (1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization". Eur. J. Biochem. 262 (1): 134–41. doi: 10.1046/j.1432-1327.1999.00363.x . PMID   10231374.
• Müschen A, Mirmohammadsadegh A, Jarzebska-Deussen B, Abts HF, Ruzicka T, Michel G (1999). "Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes". Inflamm. Res. 48 (10): 539–43. doi:10.1007/s000110050500. PMID   10563471. S2CID   22779271.
• Corinti S, Albanesi C, la Sala A, Pastore S, Girolomoni G (2001). "Regulatory activity of autocrine IL-10 on dendritic cell functions". J. Immunol. 166 (7): 4312–8. doi: 10.4049/jimmunol.166.7.4312 . PMID   11254683.
• Josephson K, Logsdon NJ, Walter MR (2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity. 15 (1): 35–46. doi: 10.1016/S1074-7613(01)00169-8 . PMID   11485736.
• Crepaldi L, Gasperini S, Lapinet JA, Calzetti F, Pinardi C, Liu Y, Zurawski S, de Waal Malefyt R, Moore KW, Cassatella MA (2001). "Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10". J. Immunol. 167 (4): 2312–22. doi: 10.4049/jimmunol.167.4.2312 . PMID   11490020.
• Zhou JH, Broussard SR, Strle K, Freund GG, Johnson RW, Dantzer R, Kelley KW (2001). "IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase". J. Immunol. 167 (8): 4436–42. doi: 10.4049/jimmunol.167.8.4436 . PMID   11591769.
• Josephson K, McPherson DT, Walter MR (2002). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D. 57 (Pt 12): 1908–11. doi:10.1107/S0907444901016249. PMID   11717514.
• Wolk K, Kunz S, Asadullah K, Sabat R (2002). "Cutting edge: immune cells as sources and targets of the IL-10 family members?". J. Immunol. 168 (11): 5397–402. doi: 10.4049/jimmunol.168.11.5397 . PMID   12023331.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.