Interleukin-21 receptor

IL21R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TGX, 4NZD
Identifiers
Aliases	IL21R , CD360, NILR, interleukin 21 receptor, IMD56
External IDs	OMIM: 605383 MGI: 1890475 HomoloGene: 11040 GeneCards: IL21R
Gene location (Human)
Chr.	Chromosome 16 (human)
End	27,452,042 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	125,232,742 bp
RNA expression pattern
	Top expressed in
	lymph node; ; blood; ; appendix; ; thymus; ; spleen; ; bone marrow; ; bone marrow cells; ; superficial temporal artery; ; right lung; ; monocyte;
	Top expressed in
	thymus; ; spleen; ; subcutaneous adipose tissue; ; ascending aorta; ; blood; ; aortic valve; ; mandible; ; supraoptic nucleus; ; dermis; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity ; interleukin-21 receptor activity ; transmembrane signaling receptor activity ;
Cellular component	integral component of membrane ; membrane ; plasma membrane ;
Biological process	natural killer cell activation ; interleukin-21-mediated signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	50615
	60504
	ENSG00000103522
	ENSMUSG00000030745
	Q9HBE5
	Q9JHX3
	NM_021798 ; NM_181078 ; NM_181079
	NM_021887
	NP_068570 ; NP_851564 ; NP_851565
	NP_068687
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene.^[5]

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma chain (γc), a receptor subunit also shared by the receptors for interleukin 2 (IL2), interleukin 7 (IL7) and interleukin 15 (IL15). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000103522 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030745 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: IL21R interleukin 21 receptor".

Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Ozaki K, Kikly K, Michalovich D, et al. (2000). "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain". Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11439–11444. Bibcode:2000PNAS...9711439O. doi: 10.1073/pnas.200360997 . PMC 17218 . PMID 11016959.
Parrish-Novak J, Dillon SR, Nelson A, et al. (2000). "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function". Nature. 408 (6808): 57–63. Bibcode:2000Natur.408...57P. doi:10.1038/35040504. PMID 11081504. S2CID 4428126.
Asao H, Okuyama C, Kumaki S, et al. (2001). "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex". J. Immunol. 167 (1): 1–5. doi: 10.4049/jimmunol.167.1.1 . PMID 11418623.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Jüngel A, Distler JH, Kurowska-Stolarska M, et al. (2004). "Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis". Arthritis Rheum. 50 (5): 1468–1476. doi: 10.1002/art.20218 . PMID 15146416.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Distler JH, Jüngel A, Kowal-Bielecka O, et al. (2005). "Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis". Arthritis Rheum. 52 (3): 856–864. doi: 10.1002/art.20883 . PMID 15751077.
Wu Z, Kim HP, Xue HH, et al. (2005). "Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity". Mol. Cell. Biol. 25 (22): 9741–9752. doi:10.1128/MCB.25.22.9741-9752.2005. PMC 1280258 . PMID 16260592.
de Totero D, Meazza R, Zupo S, et al. (2006). "Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells". Blood. 107 (9): 3708–3715. doi: 10.1182/blood-2005-09-3535 . PMID 16391014.
Pène J, Guglielmi L, Gauchat JF, et al. (2007). "IFN-gamma-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R gene". J. Immunol. 177 (8): 5006–13. doi: 10.4049/jimmunol.177.8.5006 . PMID 17015683.
Li J, Shen W, Kong K, Liu Z (2006). "Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis". Scand. J. Immunol. 64 (5): 515–522. doi: 10.1111/j.1365-3083.2006.01795.x . PMID 17032244.
Asano K, Ikegami H, Fujisawa T, et al. (2007). "Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes". Hum. Immunol. 68 (5): 384–391. doi:10.1016/j.humimm.2007.01.009. PMID 17462506.
Akamatsu N, Yamada Y, Hasegawa H, et al. (2007). "High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma". Cancer Lett. 256 (2): 196–206. doi:10.1016/j.canlet.2007.06.001. PMID 17624663.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000103522 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030745 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: IL21R interleukin 21 receptor".

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[5]

Interleukin-21 receptor

Related Research Articles

References

Further reading