Interleukin 36 receptor antagonist

Last updated

IL36RN
Protein IL1F5 PDB 1md6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL36RN , FIL1, FIL1(DELTA), FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, IL-36Ra, PSORS14, interleukin 36 receptor antagonist
External IDs OMIM: 605507; MGI: 1859325; HomoloGene: 10453; GeneCards: IL36RN; OMA:IL36RN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173170
NM_012275

NM_001146087
NM_001146088
NM_019451

RefSeq (protein)

NP_036407
NP_775262

NP_001139559
NP_001139560
NP_062324

Location (UCSC) Chr 2: 113.06 – 113.07 Mb Chr 2: 24.17 – 24.17 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 36 receptor antagonist (IL-36RA) is a member of the interleukin-36 family of cytokines. It was previously named Interleukin-1 family member 5 (IL1F5). [5] [6] [7] [8]

Contents

The protein is known to inhibit the effects of Interleukin-36 cytokines (IL-36α, IL-36β and IL-36γ) via competing with their receptor IL-36R/IL1RL2 and thereby inhibiting their proinflammatory effects. [9]

Roles in disease

Mutations in the IL-36RN gene resulting in a decrease or production of defective IL-36RA protein have been shown to cause inflammatory skin diseases including generalised pustular psoriasis, acrodermatitis continua suppurativa Hallopeau (ACH) and acute generalized exanthematous pustulosis (AGEP). [10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000136695 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026983 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". Journal of Biological Chemistry. 275 (2): 1169–1175. doi: 10.1074/jbc.275.2.1169 . PMID   10625660.
  6. Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, et al. (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochemical and Biophysical Research Communications. 263 (3): 702–706. doi:10.1006/bbrc.1999.1440. PMID   10512743.
  7. Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, et al. (Sep 2001). "A new nomenclature for IL-1-family genes". Trends in Immunology. 22 (10): 536–537. doi:10.1016/S1471-4906(01)02040-3. PMID   11574262.
  8. "Entrez Gene: IL36RN interleukin 36 receptor antagonist".
  9. Towne JE, Garka KE, Renshaw BR, Virca GD, Sims JE (2 April 2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs". The Journal of Biological Chemistry. 279 (14): 13677–13688. doi: 10.1074/jbc.M400117200 . PMID   14734551.
  10. Navarini AA, Valeyrie-Allanore L, Setta-Kaffetzi N, Barker JN, Capon F, Creamer D, et al. (July 2013). "Rare variations in IL36RN in severe adverse drug reactions manifesting as acute generalized exanthematous pustulosis". The Journal of Investigative Dermatology. 133 (7): 1904–1907. doi: 10.1038/jid.2013.44 . PMID   23358093.

Further reading