CCL15

Last updated
chemokine (C-C motif) ligand 15
Identifiers
SymbolCCL15
Alt. symbolsSCYA15, HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B
NCBI gene 6359
HGNC 10613
OMIM 601393
PDB 2HCC
RefSeq NM_032965
UniProt Q16663
Other data
Locus Chr. 17 q11.2
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Structures Swiss-model
Domains InterPro

Chemokine (C-C motif) ligand 15 (CCL15) is a small cytokine belonging to the CC chemokine family that is also known as leukotactin-1, MIP5 and HCC-2. CCL15 is expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung. [1] It is chemotactic for neutrophils, monocytes, and lymphocytes and elicits its effects by binding to cell surface chemokine receptors like CCR1 and CCR3. [2] [3] The human CCL15 gene spans four exons and is located in a head-to-tail orientation on chromosome 17 with the gene of another CC chemokine known as CCL14. [4]

References

  1. ↑ Pardigol et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Natl. Acad. Sci. 95: 6308-6313, 1998.
  2. ↑ Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.
  3. ↑ Coulin et al. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Europ. J. Biochem. 248: 507-515, 1997.
  4. ↑ Naruse et al. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics 34: 236-240, 1996.


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