Interferon beta is a protein that in humans is encoded by the IFNB1 gene. [5] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.
Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.
Interferons are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.
Interferon gamma (IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. It was also shown to be produced in human lymphocytes. or tuberculin-sensitized mouse peritoneal lymphocytes challenged with Mantoux test (PPD); the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed IFN-γ release assay used to test for tuberculosis. In humans, the IFN-γ protein is encoded by the IFNG gene.
Chemokine ligands 4 previously known as macrophage inflammatory protein (MIP-1β), is a protein which in humans is encoded by the CCL4 gene. CCL4 belongs to a cluster of genes located on 17q11-q21 of the chromosomal region. Identification and localization of the gene on the chromosome 17 was in 1990 although the discovery of MIP-1 was initiated in 1988 with the purification of a protein doublet corresponding to inflammatory activity from supernatant of endotoxin-stimulated murine macrophages. At that time, it was also named as "macrophage inflammatory protein-1" (MIP-1) due to its inflammatory properties.
Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). STAT2 sequence identity between mouse and human is only 68%.
Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.
Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene.
Laminin subunit beta-1 is a protein that in humans is encoded by the LAMB1 gene.
Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.
Ski-like protein is a protein that in humans is encoded by the SKIL gene.
DNA-binding protein A is a protein that in humans is encoded by the CSDA gene.
Interferon alpha-inducible protein 6 is a protein that in humans is encoded by the IFI6 gene.
Interferon alpha-7 is a protein that in humans is encoded by the IFNA7 gene.
Interferon alpha-14 is a protein that in humans is encoded by the IFNA14 gene.
Interferon omega-1 is a protein that in humans is encoded by the IFNW1 gene.
Interferon alpha-8 is a protein that in humans is encoded by the IFNA8 gene.
Interferon alpha-10 is a protein that in humans is encoded by the IFNA10 gene.
Interferon alpha-5 is a protein that in humans is encoded by the IFNA5 gene.
Ras-related protein Rap-1b, also known as GTP-binding protein smg p21B, is a protein that in humans is encoded by the RAP1B gene.
Interferon alpha-1/13, also known as IFN-alpha-1/13, is a protein that in humans is encoded by the IFNA1 and IFNA13 genes.
DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by the POLA1 gene.
PDB gallery | |
|---|---|
|
 | This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it. |
