IFNW1

IFNW1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3SE4
Identifiers
Aliases	IFNW1 , interferon omega 1
External IDs	OMIM: 147553 HomoloGene: 105922 GeneCards: IFNW1
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p21.3 Start 21,140,632 bp [1] End 21,141,832 bp [1]
RNA expression pattern Bgee Top expressed in brain central nervous system cerebral cortex blood prosencephalon neocortex esophagus female reproductive system More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation response to virus positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus response to exogenous dsRNA cytokine-mediated signaling pathway T cell activation involved in immune response innate immune response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3467	n/a
Ensembl	ENSG00000177047	n/a
UniProt	P05000	n/a
RefSeq (mRNA)	NM_002177	n/a
RefSeq (protein)	NP_002168	n/a
Location (UCSC)	Chr 9: 21.14 – 21.14 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Interferon omega-1 is a protein that in humans is encoded by the IFNW1 gene. ^{[3] [4]}

References

1. GRCh38: Ensembl release 89: ENSG00000177047 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID   1385305.
4. "Entrez Gene: IFNW1 interferon, omega 1".

Further reading

• Bekisz J, Schmeisser H, Hernandez J, et al. (2005). "Human interferons alpha, beta and omega". Growth Factors. 22 (4): 243–51. doi:10.1080/08977190400000833. PMID   15621727. S2CID   84918367.
• Adolf GR, Frühbeis B, Hauptmann R, et al. (1991). "Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein". Biochim. Biophys. Acta. 1089 (2): 167–74. doi:10.1016/0167-4781(91)90004-6. PMID   1647209.
• Adolf GR, Maurer-Fogy I, Kalsner I, Cantell K (1990). "Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase". J. Biol. Chem. 265 (16): 9290–5. doi: 10.1016/S0021-9258(19)38846-5 . PMID   1693148.
• Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor". J. Biol. Chem. 266 (30): 19875–7. doi: 10.1016/S0021-9258(18)54862-6 . PMID   1834641.
• Capon DJ, Shepard HM, Goeddel DV (1985). "Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides". Mol. Cell. Biol. 5 (4): 768–79. doi:10.1128/MCB.5.4.768. PMC   366781 . PMID   2985969.
• Hauptmann R, Swetly P (1985). "A novel class of human type I interferons". Nucleic Acids Res. 13 (13): 4739–49. doi:10.1093/nar/13.13.4739. PMC   321823 . PMID   3895159.
• Chen YH, Böck G, Vornhagen R, et al. (1994). "HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells". Int. Arch. Allergy Immunol. 104 (3): 227–31. doi:10.1159/000236670. PMID   7913356.
• Oritani K, Medina KL, Tomiyama Y, et al. (2000). "Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors". Nat. Med. 6 (6): 659–66. doi:10.1038/76233. PMID   10835682. S2CID   25029188.
• Cicala C, Arthos J, Selig SM, et al. (2002). "HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9380–5. Bibcode:2002PNAS...99.9380C. doi: 10.1073/pnas.142287999 . PMC   123149 . PMID   12089333.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Interferon omega-1 (IFNW1)