IFNAR2

IFNAR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N6U, 1N6V, 2HYM, 2KZ1, 2LAG, 3S8W, 3S9D, 3SE3, 3SE4
Identifiers
Aliases	IFNAR2 , IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha and beta receptor subunit 2
External IDs	OMIM: 602376; MGI: 1098243; HomoloGene: 49242; GeneCards: IFNAR2; OMA:IFNAR2 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q22.11 Start 33,205,282 bp [1] End 33,265,675 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 C3.3|16 52.82 cM Start 91,169,671 bp [2] End 91,202,477 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte oocyte granulocyte trabecular bone pylorus cartilage tissue lymph node islet of Langerhans spleen Top expressed in granulocyte right lobe of liver right kidney tail of embryo genital tubercle spleen thymus mesenteric lymph nodes internal carotid artery bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding type I interferon binding protein kinase binding type I interferon receptor activity cytokine receptor activity Cellular component integral component of membrane extracellular region plasma membrane integral component of plasma membrane membrane intracellular anatomical structure extracellular space Biological process cell surface receptor signaling pathway response to virus receptor signaling pathway via JAK-STAT regulation of type I interferon-mediated signaling pathway type I interferon signaling pathway response to interferon-alpha response to interferon-beta defense response to virus cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3455 15976 Ensembl ENSG00000159110 ENSMUSG00000022971 UniProt P48551 O35664 RefSeq (mRNA) NM_207585 NM_000874 NM_001289125 NM_001289126 NM_001289128 NM_207584 NM_001385054 NM_001385055 NM_001110498 NM_010509 NM_001347258 RefSeq (protein) NP_000865 NP_001276054 NP_001276055 NP_001276057 NP_997467 NP_997468 NP_001103968 NP_001334187 NP_034639 Location (UCSC) Chr 21: 33.21 – 33.27 Mb Chr 16: 91.17 – 91.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene. ^[5]

Function

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. ^[6]

Interactions

IFNAR2 has been shown to interact with:

• GNB2L1, ^{[7] [8]}
• IFNA2, ^[9]
• STAT1, ^{[7] [10]} and
• STAT2. ^{[10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000159110 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022971 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Novick D, Cohen B, Rubinstein M (June 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell. 77 (3): 391–400. doi:10.1016/0092-8674(94)90154-6. PMID   8181059. S2CID   140206806.
6. "Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2".
7. Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (June 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. 276 (25): 22948–53. doi: 10.1074/jbc.M100087200 . PMID   11301323.
8. Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (November 2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. 165 (9): 5127–32. doi: 10.4049/jimmunol.165.9.5127 . PMID   11046044.
9. Piehler J, Schreiber G (May 1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol. 289 (1): 57–67. doi:10.1006/jmbi.1999.2726. PMID   10339405.
10. Li X, Leung S, Kerr IM, Stark GR (April 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC   232052 . PMID   9121453.
11. Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (March 2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem. 277 (12): 9713–21. doi: 10.1074/jbc.M111161200 . PMID   11786546.

Further reading

• Caraglia M, Marra M, Pelaia G, Maselli R, Caputi M, Marsico SA, Abbruzzese A (2005). "Alpha-interferon and its effects on signal transduction pathways". J. Cell. Physiol. 202 (2): 323–35. doi: 10.1002/jcp.20137 . PMID   15389589. S2CID   4833543.
• Raz R, Cheung K, Ling L, Levy DE (1995). "Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness". Somat. Cell Mol. Genet. 21 (2): 139–45. doi:10.1007/BF02255789. PMID   7570186. S2CID   972314.
• Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE (1995). "Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster". EMBO J. 14 (20): 5100–8. doi:10.1002/j.1460-2075.1995.tb00192.x. PMC   394613 . PMID   7588638.
• Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR (1995). "Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling". J. Biol. Chem. 270 (37): 21606–11. doi: 10.1074/jbc.270.37.21606 . PMID   7665574.
• Novick D, Cohen B, Tal N, Rubinstein M (1995). "Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor". J. Leukoc. Biol. 57 (5): 712–8. doi:10.1002/jlb.57.5.712. PMID   7759950. S2CID   24680458.
• Platanias LC, Uddin S, Domanski P, Colamonici OR (1996). "Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor". J. Biol. Chem. 271 (39): 23630–3. doi: 10.1074/jbc.271.39.23630 . PMID   8798579.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Croze E, Russell-Harde D, Wagner TC, Pu H, Pfeffer LM, Perez HD (1996). "The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein". J. Biol. Chem. 271 (52): 33165–8. doi: 10.1074/jbc.271.52.33165 . PMID   8969169.
• Li X, Leung S, Kerr IM, Stark GR (1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC   232052 . PMID   9121453.
• Piehler J, Schreiber G (1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol. 289 (1): 57–67. doi:10.1006/jmbi.1999.2726. PMID   10339405.
• Chuntharapai A, Gibbs V, Lu J, Ow A, Marsters S, Ashkenazi A, De Vos A, Jin Kim K (1999). "Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2". J. Immunol. 163 (2): 766–73. doi: 10.4049/jimmunol.163.2.766 . PMID   10395669.
• Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
• Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. 165 (9): 5127–32. doi: 10.4049/jimmunol.165.9.5127 . PMID   11046044.
• Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. 276 (25): 22948–53. doi: 10.1074/jbc.M100087200 . PMID   11301323.
• Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem. 277 (12): 9713–21. doi: 10.1074/jbc.M111161200 . PMID   11786546.
• Chill JH, Nivasch R, Levy R, Albeck S, Schreiber G, Anglister J (2002). "The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening". Biochemistry. 41 (11): 3575–85. doi:10.1021/bi011778f. PMID   11888273.
• Velichko S, Wagner TC, Turkson J, Jove R, Croze E (2002). "STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues". J. Biol. Chem. 277 (38): 35635–41. doi: 10.1074/jbc.M204578200 . PMID   12105218.
• Usacheva A, Kotenko S, Witte MM, Colamonici OR (2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. 169 (3): 1302–8. doi: 10.4049/jimmunol.169.3.1302 . PMID   12133952.
• Gauzzi MC, Canini I, Eid P, Belardelli F, Gessani S (2002). "Loss of type I IFN receptors and impaired IFN responsiveness during terminal maturation of monocyte-derived human dendritic cells". J. Immunol. 169 (6): 3038–45. doi: 10.4049/jimmunol.169.6.3038 . PMID   12218119.