IL17RB

IL17RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VBC
Identifiers
Aliases	IL17RB , CRL4, EVI27, IL17BR, IL17RH1, interleukin 17 receptor B
External IDs	OMIM: 605458; MGI: 1355292; HomoloGene: 10287; GeneCards: IL17RB; OMA:IL17RB - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.1 Start 53,846,568 bp [1] End 53,865,794 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 A3|14 18.39 cM Start 29,718,092 bp [2] End 29,730,853 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule right lobe of liver human kidney mucosa of ileum right hemisphere of cerebellum glomerulus Amygdala metanephric glomerulus caudate nucleus nucleus accumbens Top expressed in secondary oocyte primary oocyte thymus zygote right kidney proximal tubule pharynx morula vestibular membrane of cochlear duct Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine receptor activity interleukin-17 receptor activity Cellular component cytoplasm integral component of membrane extracellular region cell surface integral component of plasma membrane membrane plasma membrane Biological process defense response positive regulation of inflammatory response regulation of cell growth interleukin-17-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55540 50905 Ensembl ENSG00000056736 ENSMUSG00000015966 UniProt Q9NRM6 Q9JIP3 RefSeq (mRNA) NM_018725 NM_172234 NM_019583 RefSeq (protein) NP_061195 NP_062529 Location (UCSC) Chr 3: 53.85 – 53.87 Mb Chr 14: 29.72 – 29.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene. ^{[5] [6] [7]}

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. ^[7]

See also

• Interleukin-17 receptor

References

1. GRCh38: Ensembl release 89: ENSG00000056736 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015966 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity". J Biol Chem. 275 (25): 19167–76. doi: 10.1074/jbc.M910228199 . PMID   10749887.
6. Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr (Jun 2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor". Oncogene. 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID   10815801. S2CID   27521628.
7. "Entrez Gene: IL17RB interleukin 17 receptor B".

Further reading

• Schwandner R, Yamaguchi K, Cao Z (2000). "Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction". J. Exp. Med. 191 (7): 1233–40. doi:10.1084/jem.191.7.1233. PMC   2193168 . PMID   10748240.
• Lee J, Ho WH, Maruoka M, et al. (2001). "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1". J. Biol. Chem. 276 (2): 1660–4. doi: 10.1074/jbc.M008289200 . PMID   11058597.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi: 10.1186/gb-2004-5-2-r8 . PMC   395752 . PMID   14759258.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Symmans WF (2006). "Genomic testing for sensitivity of breast cancer to hormonal therapy". Clin. Cancer Res. 12 (7 Pt 1): 1954–5. doi: 10.1158/1078-0432.CCR-06-0289 . PMID   16609001.
• Goetz MP, Suman VJ, Ingle JN, et al. (2006). "A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen". Clin. Cancer Res. 12 (7 Pt 1): 2080–7. doi:10.1158/1078-0432.CCR-05-1263. PMID   16609019. S2CID   9930864.
• Ma XJ, Hilsenbeck SG, Wang W, et al. (2006). "The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer". J. Clin. Oncol. 24 (28): 4611–9. doi: 10.1200/JCO.2006.06.6944 . PMID   17008703.

External links

• IL17RB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.