Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene. [5] [6] [7]
The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor. [5]
Interferon gamma receptor 1 has been shown to interact with Interferon-gamma. [8] [9]
Mutations in the IFNGR1 gene can lead to extreme susceptibility to Mycobacterial infections. [10] [11] All known mutations and common variations in the IFNGR1 are present in the IFNGR1 mutation database. [12] [13]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.