CD248

Last updated
CD248
Identifiers
Aliases CD248 , CD164L1, TEM1, CD248 molecule
External IDs OMIM: 606064 MGI: 1917695 HomoloGene: 10699 GeneCards: CD248
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020404

NM_054042

RefSeq (protein)

NP_065137

NP_473383

Location (UCSC) Chr 11: 66.31 – 66.32 Mb Chr 19: 5.12 – 5.12 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Endosialin is a protein that in humans is encoded by the CD248 gene. [5] [6] [7]

Contents

Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise three other members, CLEC14A, CD93 and Thrombomodulin the latter of which are better characterized. [8]

The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo and uterus and in tumor development and growth. [9]

See also

Related Research Articles

<span class="mw-page-title-main">DC-SIGN</span> Protein-coding gene in the species Homo sapiens

DC-SIGN also known as CD209 is a protein which in humans is encoded by the CD209 gene.

<span class="mw-page-title-main">Thrombomodulin</span>

Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is also expressed on human mesothelial cell, monocyte and a dendritic cell subset.

<span class="mw-page-title-main">OLR1</span> Protein-coding gene in the species Homo sapiens

Oxidized low-density lipoprotein receptor 1 also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.

<span class="mw-page-title-main">Melanotransferrin</span> Protein-coding gene in the species Homo sapiens

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228.

<span class="mw-page-title-main">CLEC4M</span> Protein-coding gene in the species Homo sapiens

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene. CLEC4M has also been designated as CD299.

<span class="mw-page-title-main">LMAN1</span> Protein-coding gene in the species Homo sapiens

Protein ERGIC-53 also known as ER-Golgi intermediate compartment 53 kDa protein or lectin mannose-binding 1 is a protein that in humans is encoded by the LMAN1 gene.

<span class="mw-page-title-main">CD93</span>

CD93 is a protein that in humans is encoded by the CD93 gene. CD93 is a C-type lectin transmembrane receptor which plays a role not only in cell–cell adhesion processes but also in host defense.

<span class="mw-page-title-main">Fibroblast activation protein, alpha</span>

Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene.

<span class="mw-page-title-main">LGALS3BP</span> Protein-coding gene in the species Homo sapiens

Galectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene.

<span class="mw-page-title-main">ANTXR1</span> Protein-coding gene in the species Homo sapiens

Anthrax toxin receptor 1 is a protein that in humans is encoded by the ANTXR1 gene. Its molecular weight is predicted as about 63kDa.

<span class="mw-page-title-main">HSPH1</span> Protein-coding gene in the species Homo sapiens

Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene.

<span class="mw-page-title-main">SIGLEC7</span> Protein-coding gene in the species Homo sapiens

Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene. SIGLEC7 has also been designated as CD328.

<span class="mw-page-title-main">LIMA1</span>

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.

<span class="mw-page-title-main">SIGLEC5</span> Protein-coding gene in the species Homo sapiens

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. SIGLEC5 has also been designated CD170.

<span class="mw-page-title-main">CLEC1B</span> Protein-coding gene in the species Homo sapiens

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.

<span class="mw-page-title-main">Galectin-4</span> Protein-coding gene in the species Homo sapiens

Galectin-4 is a protein that in humans is encoded by the LGALS4 gene.

<span class="mw-page-title-main">SIGLEC10</span> Protein-coding gene in the species Homo sapiens

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene. Siglec-G is often referred to as the murine paralog of human Siglec-10

<span class="mw-page-title-main">PLXDC1</span> Protein-coding gene in the species Homo sapiens

Plexin domain-containing protein 1 is a protein that in humans is encoded by the PLXDC1 gene.

<span class="mw-page-title-main">CLEC10A</span> Protein-coding gene in the species Homo sapiens

C-type lectin domain family 10 member A (CLEC10A) also designated as CD301 is a protein that in humans is encoded by the CLEC10A gene. CLEC10A is part of the C-type lectin superfamily and binds to N-Acetylgalactosamine (GalNAc). It is mainly expressed on myeloid cells and also on oocytes and very early stages of embryogenesis. CLEC10A is used as a marker of the CD1c+ dendritic cell subgroup, also called cDC2. The actions of CLEC10A are diverse, depending on the ligand and environment.

Oncomatryx Biopharma S. L. is a pharmaceutical biotechnology company that develops personalized treatments against invasive cancer as well as tests for its early detection. Established by Laureano Simón, PhD, Oncomatryx thus engages twofold in the fight against invasive kinds of cancer, such as pancreatic cancer or invasive breast cancer, all of which have high mortality rates.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000174807 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056481 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. Bibcode:2000Sci...289.1197S. doi:10.1126/science.289.5482.1197. PMID   10947988.
  6. Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC (May 2001). "Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium". J Biol Chem. 276 (10): 7408–14. doi: 10.1074/jbc.M009604200 . PMID   11084048.
  7. "Entrez Gene: CD248 CD248 molecule, endosialin".
  8. Khan KA, McMurray J, Mohammed FM, Bicknell R (2019). "C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation". FEBS Journal. 286 (17): 3299–3332. doi:10.1111/febs.14985. PMC   6852297 . PMID   31287944.
  9. Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P (2006). "Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis". Cancer Immun. 6: 10. PMID   16875435.

Further reading