Fibroblast growth factor receptor 4

Last updated
FGFR4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FGFR4 , CD334, JTK2, TKF, fibroblast growth factor receptor 4
External IDs OMIM: 134935 MGI: 95525 HomoloGene: 20461 GeneCards: FGFR4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291980
NM_002011
NM_022963
NM_213647
NM_001354984

NM_008011

RefSeq (protein)

NP_001278909
NP_002002
NP_075252
NP_998812
NP_001341913

NP_032037

Location (UCSC) Chr 5: 177.09 – 177.1 Mb Chr 13: 55.3 – 55.32 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster of differentiation 334).

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [5] In a meta-analisis study, the functional polymorphism Gly388Arg (rs351855) of FGFR4 was observed to be significantly associated with nodal involvement and overall survival in patients with different types of cancer. [6]

Interactions

Fibroblast growth factor receptor 4 has been shown to interact with FGF1. [7] [8]

Related Research Articles

Receptor tyrosine kinase Class of enzymes

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins. Receptor tyrosine kinases have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Mutations in receptor tyrosine kinases lead to activation of a series of signalling cascades which have numerous effects on protein expression. Receptor tyrosine kinases are part of the larger family of protein tyrosine kinases, encompassing the receptor tyrosine kinase proteins which contain a transmembrane domain, as well as the non-receptor tyrosine kinases which do not possess transmembrane domains.

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.

Adapter molecule crk Protein-coding gene in the species Homo sapiens

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

Related to receptor tyrosine kinase

The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk.

Fibroblast growth factor receptor 1 Protein-coding gene in the species Homo sapiens

Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome, and clonal eosinophilias.

GRB10

Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.

IRS2

Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.

FRS2

Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.

GAS6 Human gene coding for the GAS6 protein

Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.

PTPN12

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

Megakaryocyte-associated tyrosine kinase Protein-coding gene in the species Homo sapiens

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.

MST1

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein, is a protein that in humans is encoded by the MST1 gene.

TYRO3

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.

GRB14

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.

IRS4 Protein-coding gene in the species Homo sapiens

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.

FRS3

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.

Fibroblast growth factor receptor-like 1 Protein-coding gene in the species Homo sapiens

Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene.

FGF6

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.

FLT4

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.

Kari Alitalo Finnish MD and a medical researcher

Kari Kustaa Alitalo is a Finnish MD and a medical researcher. He is a foreign associated member of the National Academy of Sciences of the US. He became famous for his discoveries of several receptor tyrosine kinases (RTKs) and the first growth factor capable of inducing lymphangiogenesis: vascular endothelial growth factor C (VEGF-C). In the years 1996–2007 he was Europe's second most cited author in the field of cell biology. Alitalo is currently serving as an Academy Professor for the Academy of Finland.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160867 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005320 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FGFR4 fibroblast growth factor receptor 4".
  6. Frullanti, E (2011). "Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor". Eur J Cancer Prev. 20 (4): 340–347. doi:10.1097/CEJ.0b013e3283457274. PMID   21412156. S2CID   29668012.
  7. Loo, B B; Darwish K K; Vainikka S S; Saarikettu J J; Vihko P P; Hermonen J J; Goldman A A; Alitalo K K; Jalkanen M M (May 2000). "Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4". Int. J. Biochem. Cell Biol. ENGLAND. 32 (5): 489–97. doi:10.1016/S1357-2725(99)00145-4. ISSN   1357-2725. PMID   10736564.
  8. Kan, M; Wu X; Wang F; McKeehan W L (May 1999). "Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase". J. Biol. Chem. UNITED STATES. 274 (22): 15947–52. doi: 10.1074/jbc.274.22.15947 . ISSN   0021-9258. PMID   10336501.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.