EPHB3

Last updated
EPHB3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EPHB3 , ETK2, HEK2, TYRO6, EPH receptor B3, EK2
External IDs OMIM: 601839; MGI: 104770; HomoloGene: 20938; GeneCards: EPHB3; OMA:EPHB3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004443

NM_010143

RefSeq (protein)

NP_004434

NP_034273

Location (UCSC) Chr 3: 184.56 – 184.58 Mb Chr 16: 21.02 – 21.04 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene. [5] [6]

Contents

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [6]

Interactions

EPHB3 has been shown to interact with MLLT4 [7] and RAS p21 protein activator 1. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182580 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005958 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Böhme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K, Rübsamen-Waigmann H (Oct 1993). "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2". Oncogene. 8 (10): 2857–62. PMID   8397371.
  6. 1 2 "Entrez Gene: EPHB3 EPH receptor B3".
  7. Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rübsamen-Waigmann H, Strebhardt K (Aug 1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. Bibcode:1998PNAS...95.9779H. doi: 10.1073/pnas.95.17.9779 . PMC   21413 . PMID   9707552.
  8. Hock B, Böhme B, Karn T, Feller S, Rübsamen-Waigmann H, Strebhardt K (Jul 1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions". Oncogene. 17 (2): 255–60. doi: 10.1038/sj.onc.1201907 . PMID   9674711.

Further reading