EPHA8

Last updated
EPHA8
Protein EPHA8 PDB 1ucv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EPHA8 , EEK, EK3, HEK3, EPH receptor A8
External IDs OMIM: 176945 MGI: 109378 HomoloGene: 22436 GeneCards: EPHA8
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001006943
NM_020526

NM_007939

RefSeq (protein)

NP_001006944
NP_065387

NP_031965

Location (UCSC) Chr 1: 22.56 – 22.6 Mb Chr 4: 136.93 – 136.96 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene. [5] [6]

Contents

Function

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [6]

Interactions

EPHA8 has been shown to interact with FYN. [7]

Related Research Articles

<span class="mw-page-title-main">Ephrin receptor</span> Protein family

Eph receptors are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins). Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Eph receptors and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell interactions for Eph receptor activation. Eph/ephrin signaling has been implicated in the regulation of a host of processes critical to embryonic development including axon guidance, formation of tissue boundaries, cell migration, and segmentation. Additionally, Eph/ephrin signaling has been identified to play a critical role in the maintenance of several processes during adulthood including long-term potentiation, angiogenesis, and stem cell differentiation and cancer.

<span class="mw-page-title-main">Ephrin B2</span>

Ephrin-B2 is a protein that in humans is encoded by the EFNB2 gene.

<span class="mw-page-title-main">Ephrin B1</span> Protein-coding gene in the species Homo sapiens

Ephrin B1 is a protein that in humans is encoded by the EFNB1 gene. It is a member of the ephrin family. The encoded protein is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.

<span class="mw-page-title-main">EPH receptor B2</span> Protein-coding gene in the species Homo sapiens

Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene.

<span class="mw-page-title-main">EPH receptor A2</span> Protein-coding gene in the species Homo sapiens

EPH receptor A2 is a protein that in humans is encoded by the EPHA2 gene.

<span class="mw-page-title-main">EPH receptor B4</span> Protein-coding gene in the species Homo sapiens

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.

<span class="mw-page-title-main">Ephrin A1</span> Protein-coding gene in the species Homo sapiens

Ephrin A1 is a protein that in humans is encoded by the EFNA1 gene.

<span class="mw-page-title-main">EPH receptor A4</span>

EPH receptor A4 is a protein that in humans is encoded by the EPHA4 gene.

<span class="mw-page-title-main">EPH receptor B1</span>

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.

<span class="mw-page-title-main">EPH receptor A3</span>

EPH receptor A3 is a protein that in humans is encoded by the EPHA3 gene.

<span class="mw-page-title-main">EPHB6</span> Protein-coding gene in the species Homo sapiens

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.

<span class="mw-page-title-main">EPHA7</span>

Ephrin type-A receptor 7 is a protein that in humans is encoded by the EPHA7 gene.

<span class="mw-page-title-main">EPH receptor A5</span> Protein-coding gene in the species Homo sapiens

EPH receptor A5 is a protein that in humans is encoded by the EPHA5 gene.

<span class="mw-page-title-main">Ephrin A4</span> Protein-coding gene in the species Homo sapiens

Ephrin A4 is a protein that in humans is encoded by the EFNA4 gene.

<span class="mw-page-title-main">Ephrin A2</span> Protein-coding gene in the species Homo sapiens

Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene.

<span class="mw-page-title-main">Ephrin A3</span> Protein-coding gene in the species Homo sapiens

Ephrin A3 is a protein that in humans is encoded by the EFNA3 gene.

<span class="mw-page-title-main">Ephrin B3</span> Protein-coding gene in the species Homo sapiens

Ephrin-B3 is a protein that in humans is encoded by the EFNB3 gene.

<span class="mw-page-title-main">EPH receptor A1</span> Protein-coding gene in the species Homo sapiens

EPH receptor A1 is a protein that in humans is encoded by the EPHA1 gene.

<span class="mw-page-title-main">EPHB3</span>

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.

<span class="mw-page-title-main">Ephrin A5</span> Protein-coding gene in the species Homo sapiens

Ephrin A5 is a protein that in humans is encoded by the EFNA5 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000070886 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028661 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chan J, Watt VM (Aug 1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases". Oncogene. 6 (6): 1057–61. PMID   1648701.
  6. 1 2 "Entrez Gene: EPHA8 EPH receptor A8".
  7. Choi S, Park S (Sep 1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene. 18 (39): 5413–22. doi: 10.1038/sj.onc.1202917 . PMID   10498895.

Further reading