EPHA8

EPHA8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UCV, 1X5L, 3KUL
Identifiers
Aliases	EPHA8 , EEK, EK3, HEK3, EPH receptor A8
External IDs	OMIM: 176945 MGI: 109378 HomoloGene: 22436 GeneCards: EPHA8
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.12 Start 22,563,489 bp [1] End 22,603,595 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D3 Start 136,929,419 bp [2] End 136,956,816 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell spleen hypothalamus secondary oocyte mesencephalon substantia nigra prefrontal cortex cingulate gyrus superior frontal gyrus occipital lobe Top expressed in cerebellar cortex visual cortex superior frontal gyrus entorhinal cortex lens superior colliculus habenula neuron pretectal area basal forebrain More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity GPI-linked ephrin receptor activity receptor tyrosine kinase transmembrane signaling receptor activity transmembrane-ephrin receptor activity Cellular component integral component of membrane endosome cell projection early endosome membrane membrane integral component of plasma membrane plasma membrane neuron projection cytoplasm receptor complex Biological process phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway nervous system development multicellular organism development protein phosphorylation cell adhesion peptidyl-tyrosine phosphorylation substrate-dependent cell migration protein autophosphorylation axon guidance neuron projection development regulation of cell adhesion regulation of cell adhesion mediated by integrin neuron remodeling positive regulation of phosphatidylinositol 3-kinase activity ephrin receptor signaling pathway positive regulation of MAPK cascade cellular response to follicle-stimulating hormone stimulus negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2046 13842 Ensembl ENSG00000070886 ENSMUSG00000028661 UniProt P29322 O09127 RefSeq (mRNA) NM_001006943 NM_020526 NM_007939 RefSeq (protein) NP_001006944 NP_065387 NP_031965 Location (UCSC) Chr 1: 22.56 – 22.6 Mb Chr 4: 136.93 – 136.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene. ^{[5] [6]}

Function

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. ^[6]

Interactions

EPHA8 has been shown to interact with FYN. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000070886 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028661 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chan J, Watt VM (Aug 1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases". Oncogene. 6 (6): 1057–61. PMID   1648701.
6. "Entrez Gene: EPHA8 EPH receptor A8".
7. Choi S, Park S (Sep 1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene. 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID   10498895. S2CID   11001580.

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID   9530499.
• Holland SJ, Peles E, Pawson T, Schlessinger J (1998). "Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta". Curr. Opin. Neurobiol. 8 (1): 117–27. doi: 10.1016/S0959-4388(98)80015-9 . PMID   9568399. S2CID   34141508.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID   9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. doi:10.1242/dev.126.10.2033. PMID   10207129.
• Wilkinson DG (2000). Eph receptors and ephrins: regulators of guidance and assembly. International Review of Cytology. Vol. 196. pp. 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN   978-0-12-364600-2. PMID   10730216.{{cite book}}: |journal= ignored (help)
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC   1692797 . PMID   11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID   11256076. S2CID   205014301.
• Nakamoto T, Kain KH, Ginsberg MH (2004). "Neurobiology: New connections between integrins and axon guidance". Curr. Biol. 14 (3): R121–3. Bibcode:2004CBio...14.R121N. doi: 10.1016/j.cub.2004.01.020 . PMID   14986683. S2CID   2957639.
• Yamaguchi Y, Pasquale EB (2004). "Eph receptors in the adult brain". Curr. Opin. Neurobiol. 14 (3): 288–96. doi:10.1016/j.conb.2004.04.003. PMID   15194108. S2CID   26196696.
• Murai KK, Pasquale EB (2004). "Eph receptors, ephrins, and synaptic function". The Neuroscientist. 10 (4): 304–14. doi:10.1177/1073858403262221. PMID   15271258. S2CID   23900846.
• Park S, Sánchez MP (1997). "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands". Oncogene. 14 (5): 533–42. doi:10.1038/sj.onc.1200857. PMID   9053851. S2CID   21779523.
• Park S, Frisén J, Barbacid M (1997). "Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors". EMBO J. 16 (11): 3106–14. doi:10.1093/emboj/16.11.3106. PMC   1169929 . PMID   9214628.
• Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi: 10.1016/S0092-8674(00)80500-0 . PMID   9267020. S2CID   26773768.
• Lemke G (1998). "A coherent nomenclature for Eph receptors and their ligands". Mol. Cell. Neurosci. 9 (5–6): 331–2. doi:10.1006/mcne.1997.0630. PMID   9361271. S2CID   6608696.
• Choi S, Park S (1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene. 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID   10498895. S2CID   11001580.