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Trade names | Oxervate |
Other names | Recombinant human nerve growth factor; rhNGF, cenegermin-bkbj |
AHFS/Drugs.com | Monograph |
MedlinePlus | a619001 |
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Routes of administration | Ophthalmic |
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Chemical and physical data | |
Formula | C583H908N166O173S8 |
Molar mass | 13267.15 g·mol−1 |
Cenegermin, sold under the brand name Oxervate, also known as recombinant human nerve growth factor, is a recombinant form of human nerve growth factor. [4] Cenegermin is a peripherally selective agonist of the tropomyosin receptor kinase A (TrkA) and low-affinity nerve growth factor receptor (p75NTR). [4]
The most common side effects include eye pain and inflammation, increased lacrimation (watery eyes), pain in the eyelid and sensation of a foreign body in the eye. [5]
It was approved for medical use in the European Union in July 2017, [5] and in the United States in 2018. [4] [6] The US Food and Drug Administration (FDA) considers it to be a first-in-class medication. [6]
Cenegermin is indicated for the treatment of neurotrophic keratitis. [4] [5]
Cenegermin is the international nonproprietary name. [7] It is also known as human beta-nerve growth factor (beta-NGF)-(1-118) peptide (non-covalent dimer) produced in Escherichia coli . [7]
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